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@ARTICLE{Pikhovych:810957,
author = {Pikhovych, A. and Walter, H. L. and Mahabir, E. and Fink,
G. R. and Graf, R. and Schroeter, M. and Rueger, M. A.},
title = {{T}ranscranial direct current stimulation in the male mouse
to promote recovery after stroke},
journal = {Laboratory animals},
volume = {50},
number = {3},
issn = {1758-1117},
address = {London},
publisher = {Sage},
reportid = {FZJ-2016-03513},
pages = {212 - 216},
year = {2016},
abstract = {Transcranial direct current stimulation (tDCS) constitutes
a promising approach for promoting recovery of function
after stroke, although the underlying neurobiological
mechanisms are unclear. To conduct translational research in
animal models, stimulation parameters should not lead to
neuronal lesions. Liebetanz et al. recommend charge
densities for cathodal stimulation in rats, but parameters
for mice are not established. We established tDCS in the
wild-type mouse, enabling studies with
genetically-engineered mice (GEM). tDCS equipment was
adapted to fit the mouse skull. Using different polarities
and charge densities, tDCS was safe to apply in the mouse
where the charge density was below 198 kC/m2 for single or
repeated stimulations. These findings are crucial for future
investigations of the neurobiological mechanisms underlying
tDCS using GEM.},
cin = {INM-3},
ddc = {610},
cid = {I:(DE-Juel1)INM-3-20090406},
pnm = {572 - (Dys-)function and Plasticity (POF3-572)},
pid = {G:(DE-HGF)POF3-572},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000376294600006},
doi = {10.1177/0023677215610708},
url = {https://juser.fz-juelich.de/record/810957},
}