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@ARTICLE{Rsch:811049,
      author       = {Rösch, Sarah and Aretzweiler, Christoph and Müller, Frank
                      and Walter, Peter},
      title        = {{E}valuation of {R}etinal {F}unction and {M}orphology of
                      the {P}ink-{E}yed {R}oyal {C}ollege of {S}urgeons ({RCS})
                      {R}at: {A} {C}omparative {S}tudy of in {V}ivo and in {V}itro
                      {M}ethods},
      journal      = {Current eye research},
      volume       = {42},
      number       = {2},
      issn         = {1460-2202},
      address      = {London},
      publisher    = {Informa Healthcare},
      reportid     = {FZJ-2016-03572},
      pages        = {273-281},
      year         = {2017},
      abstract     = {To characterize the course of retinal degeneration in the
                      pink-eyed RCS rat in vivo and in vitro.Retinal function of
                      RCS rats at the age of 2 to 100 weeks was determined in vivo
                      using full-field electroretinography (ERG). Retinal
                      morphology was evaluated in vivo using spectral domain
                      Optical Coherence Tomography (sd-OCT) and Fluorescence
                      angiography (FA) as well as postmortem using
                      immunohistochemistry (IH). As a control, retinal function
                      and morphology of non-dystrophic Wistar rats were
                      analyzed.RCS rats showed an extinction of the ERG beginning
                      with the age of 4 weeks. In the OCT, the outer part of the
                      retina (OPR) could be clearly distinguished from the inner
                      part of the retina (IPR) until the age of 8 weeks. However,
                      at this age, it was impossible to determine from OCT images
                      whether the OPR was formed by the outer nuclear layer (ONL)
                      or by cellular debris built in the course of retinal
                      degeneration. In contrast, immunohistochemistry always
                      enabled to differentiate between ONL and debris (RCS 4 weeks
                      of age: OPR mainly formed by ONL; RCS 8 weeks of age: OPR
                      consisted mainly of cell debris, only 1-2 cell rows of
                      photoreceptor somata were left).In general, data obtained in
                      vivo were confirmed by data obtained post mortem. Apart from
                      the problem to differentiate between debris and ONL at the
                      age of 8 weeks in the RCS rat, ERG and OCT are useful
                      methods to evaluate retinal function and structure in vivo
                      and to complement immunohistochemical analysis of the
                      degeneration process.},
      cin          = {ICS-4},
      ddc          = {610},
      cid          = {I:(DE-Juel1)ICS-4-20110106},
      pnm          = {553 - Physical Basis of Diseases (POF3-553)},
      pid          = {G:(DE-HGF)POF3-553},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27362633},
      UT           = {WOS:000395186800016},
      doi          = {10.1080/02713683.2016.1179333},
      url          = {https://juser.fz-juelich.de/record/811049},
}