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@ARTICLE{Vickery:811524,
      author       = {Vickery, Owen N. and Machtens, Jan-Philipp and Tamburrino,
                      Giulia and Seeliger, Daniel and Zachariae, Ulrich},
      title        = {{S}tructural {M}echanisms of {V}oltage {S}ensing in
                      {G} {P}rotein-{C}oupled {R}eceptors},
      journal      = {Structure},
      volume       = {24},
      number       = {6},
      issn         = {0969-2126},
      address      = {London [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2016-03981},
      pages        = {997 - 1007},
      year         = {2016},
      abstract     = {G-protein-coupled receptors (GPCRs) form the largest
                      superfamily of membrane proteins and one-third of all drug
                      targets in humans. A number of recent studies have reported
                      evidence for substantial voltage regulation of GPCRs.
                      However, the structural basis of GPCR voltage sensing has
                      remained enigmatic. Here, we present atomistic simulations
                      on the δ-opioid and M2 muscarinic receptors, which suggest
                      a structural and mechanistic explanation for the observed
                      voltage-induced functional effects. The simulations reveal
                      that the position of an internal Na+ ion, recently detected
                      to bind to a highly conserved aqueous pocket in receptor
                      crystal structures, strongly responds to voltage changes.
                      The movements give rise to gating charges in excellent
                      agreement with previous experimental recordings.
                      Furthermore, free energy calculations show that these
                      rearrangements of Na+ can be induced by physiological
                      membrane voltages. Due to its role in receptor function and
                      signal bias, the repositioning of Na+ has important general
                      implications for signal transduction in GPCRs.},
      cin          = {ICS-4 / JARA-HPC},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-4-20110106 / $I:(DE-82)080012_20140620$},
      pnm          = {552 - Engineering Cell Function (POF3-552) / MOLECULAR
                      MODELLING OF BIFUNCTIONAL MEMBRANE TRANSPORT PROTEINS
                      $(jics40_20130501)$},
      pid          = {G:(DE-HGF)POF3-552 / $G:(DE-Juel1)jics40_20130501$},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000377782200020},
      pubmed       = {pmid:27210286},
      doi          = {10.1016/j.str.2016.04.007},
      url          = {https://juser.fz-juelich.de/record/811524},
}