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@ARTICLE{Pikhovych:811554,
      author       = {Pikhovych, Anton and Stolberg, Nina Paloma and Jessica
                      Flitsch, Lea and Walter, Helene Luise and Graf, Rudolf and
                      Fink, Gereon Rudolf and Schroeter, Michael and Rueger, Maria
                      Adele},
      title        = {{T}ranscranial {D}irect {C}urrent {S}timulation {M}odulates
                      {N}eurogenesis and {M}icroglia {A}ctivation in the {M}ouse
                      {B}rain},
      journal      = {Stem cells international},
      volume       = {2016},
      issn         = {1687-9678},
      address      = {London [u.a.]},
      publisher    = {Sage-Hindawi},
      reportid     = {FZJ-2016-03998},
      pages        = {Article ID 2715196},
      year         = {2016},
      abstract     = {Transcranial direct current stimulation (tDCS) has been
                      suggested as an adjuvant tool to promote recovery of
                      function after stroke, but the mechanisms of its action to
                      date remain poorly understood. Moreover, studies aimed at
                      unraveling those mechanisms have essentially been limited to
                      the rat, where tDCS activates resident microglia as well as
                      endogenous neural stem cells. Here we studied the effects of
                      tDCS on microglia activation and neurogenesis in the mouse
                      brain. Male wild-type mice were subjected to multisession
                      tDCS of either anodal or cathodal polarity; sham-stimulated
                      mice served as control. Activated microglia in the cerebral
                      cortex and neuroblasts generated in the subventricular zone
                      as the major neural stem cell niche were assessed
                      immunohistochemically. Multisession tDCS at a sublesional
                      charge density led to a polarity-dependent downregulation of
                      the constitutive expression of Iba1 by microglia in the
                      mouse cortex. In contrast, both anodal and, to an even
                      greater extent, cathodal tDCS induced neurogenesis from the
                      subventricular zone. Data suggest that tDCS elicits its
                      action through multifacetted mechanisms, including
                      immunomodulation and neurogenesis, and thus support the idea
                      of using tDCS to induce regeneration and to promote recovery
                      of function. Furthermore, data suggest that the effects of
                      tDCS may be animal- and polarity-specific.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000378771000001},
      pubmed       = {pmid:27403166},
      doi          = {10.1155/2016/2715196},
      url          = {https://juser.fz-juelich.de/record/811554},
}