TY  - JOUR
AU  - Galldiks, Norbert
AU  - Langen, Karl-Josef
TI  - Amino Acid PET – An Imaging Option to Identify Treatment Response, Posttherapeutic Effects, and Tumor Recurrence?
JO  - Frontiers in neurology
VL  - 7
SN  - 1664-2295
CY  - Lausanne
PB  - Frontiers Research Foundation
M1  - FZJ-2016-04070
SP  - 120
PY  - 2016
AB  - Routine diagnostics and treatment monitoring in patients with primary and secondary brain tumors is usually based on contrast-enhanced standard MRI. However, the capacity of standard MRI to differentiate neoplastic tissue from non-specific posttreatment effects may be limited particularly after therapeutic interventions such as radio- and/or chemotherapy or newer treatment options, e.g., immune therapy. Metabolic imaging using PET may provide relevant additional information on tumor metabolism, which allows a more accurate diagnosis especially in clinically equivocal situations, particularly when radiolabeled amino acids are used. Amino acid PET allows a sensitive monitoring of a response to various treatment options, the early detection of tumor recurrence, and an improved differentiation of tumor recurrence from posttherapeutic effects. In the past, this method had only limited availability due to the use of PET tracers with a short half-life, e.g., C-11. In recent years, however, novel amino acid PET tracers labeled with positron emitters with a longer half-life (F-18) have been developed and clinically validated, which allow a more efficient and cost-effective application. These developments and the well-documented diagnostic performance of PET using radiolabeled amino acids suggest that its application continues to spread and that this technique may be available as a routine diagnostic tool for several indications in the field of neuro-oncology.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000381072100001
C6  - pmid:27516754
DO  - DOI:10.3389/fneur.2016.00120
UR  - https://juser.fz-juelich.de/record/811686
ER  -