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@ARTICLE{McDonough:811809,
      author       = {McDonough, Ian M. and Bischof, Gérard N. and Kennedy,
                      Kristen M. and Rodrigue, Karen M. and Farrell, Michelle E.
                      and Park, Denise C.},
      title        = {{D}iscrepancies between fluid and crystallized ability in
                      healthy adults: a behavioral marker of preclinical
                      {A}lzheimer's disease},
      journal      = {Neurobiology of aging},
      volume       = {46},
      issn         = {0197-4580},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2016-04160},
      pages        = {68 - 75},
      year         = {2016},
      abstract     = {Measures of core cognitive processes (fluid abilities) are
                      highly correlated with measures of knowledge (crystallized
                      abilities) in healthy adults. In early stages of Alzheimer's
                      disease (AD), fluid abilities, however, decline more rapidly
                      than crystallized abilities. We hypothesized that
                      cognitively normal older adults who evidenced lower fluid
                      ability compared with crystallized ability (an ability
                      discrepancy) would show evidence of early AD neuropathology
                      indexed via in vivo measures of amyloid-beta (Aβ)
                      deposition and cortical thickness in AD-vulnerable regions.
                      A sample of older adults (n = 112) aged 65 to 89 underwent a
                      cognitive battery, structural magnetic resonance imaging,
                      and a subset (n = 75) also completed positron emission
                      tomography scanning to measure Aβ deposition using F-18
                      Florbetapir. Of this sample, 60 older adults (43 with
                      available positron emission tomography scans) evidenced a
                      discrepancy where fluid ability was lower than crystallized
                      ability. The magnitude of the ability discrepancy was
                      independently associated with a greater Aβ deposition and
                      thinner cortex in AD-vulnerable regions, as well as age. The
                      data suggest that such a discrepancy may be a marker of
                      preclinical AD.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000386973900008},
      pubmed       = {pmid:27460151},
      doi          = {10.1016/j.neurobiolaging.2016.06.011},
      url          = {https://juser.fz-juelich.de/record/811809},
}