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000817706 1001_ $$0P:(DE-Juel1)156429$$aMachtens, Jan-Philipp$$b0$$eCorresponding author
000817706 1112_ $$a60th Annual Meeting of the Biophysical-Society$$cLos Angeles, CA$$d2016-02-27 - 2016-03-02$$wUSA
000817706 245__ $$aGating charge calculations: Probing voltage-sensing proteins through computational electrophysiology
000817706 260__ $$aCambridge, Mass.$$bCell Press$$c2016
000817706 300__ $$a106A
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000817706 520__ $$aSensitivity to voltage stimuli is a defining property of electrical excitability and is found in ion channels with dedicated voltage sensors, but also in other channels, transporters and even metabotropic receptors. Voltage dependence is conferred by an effective transmembrane charge transfer that can be attributed to global or localized conformational changes, ion or ligand binding, protonation or changes in water accessibility that reshape the electric field.
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000817706 7001_ $$0P:(DE-Juel1)136837$$aFahlke, Christoph$$b3
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