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@INPROCEEDINGS{Vickery:817958,
      author       = {Vickery, O. N. and Machtens, Jan-Philipp and Tamburrino, G.
                      and Seeliger, D. and Zachariae, U.},
      title        = {{I}nternal sodium in {GPCR}s strongly responds to
                      transmembrane voltage changes},
      journal      = {Biophysical journal},
      volume       = {110},
      number       = {3},
      issn         = {0006-3495},
      address      = {Cambridge, Mass.},
      publisher    = {Cell Press},
      reportid     = {FZJ-2016-04537},
      pages        = {425a-426a},
      year         = {2016},
      abstract     = {G protein-coupled receptors (GPCRs) are the largest
                      superfamily of membrane proteins in the human genome,
                      mediating the propagation of extracellular ligand binding
                      information into intracellular signal transduction cascades.
                      Crystal structures have revealed a water-filled hydrophilic
                      internal pocket within their transmembrane domain, extending
                      from the orthosteric ligand-binding site to regions near the
                      G protein binding site. Recent high-resolution structures
                      have identified a sodium ion near the base of this pocket,
                      coordinated by highly conserved residues (1,2).},
      month         = {Feb},
      date          = {2016-02-27},
      organization  = {60th Annual Meeting of the
                       Biophysical-Society, Los Angeles, CA
                       (USA), 27 Feb 2016 - 2 Mar 2016},
      cin          = {ICS-4},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-4-20110106},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16 / PUB:(DE-HGF)8},
      UT           = {WOS:000375142700079},
      doi          = {10.1016/j.bpj.2015.11.2300},
      url          = {https://juser.fz-juelich.de/record/817958},
}