TY  - JOUR
AU  - Hussein, Amr
AU  - Furth, Christian
AU  - Schönberger, Stefan
AU  - Hundsdoerfer, Patrick
AU  - Steffen, Ingo
AU  - Amthauer, Holger
AU  - Müller, Hans-Wilhelm
AU  - Hautzel, Hubertus
TI  - FDG-PET Response Prediction in Pediatric Hodgkin’s Lymphoma: Impact of Metabolically Defined Tumor Volumes and Individualized SUV Measurements on the Positive Predictive Value
JO  - Cancers
VL  - 7
IS  - 1
SN  - 2072-6694
CY  - Basel
PB  - MDPI
M1  - FZJ-2016-04543
SP  - 287 - 304
PY  - 2015
AB  - Background: In pediatric Hodgkin’s lymphoma (pHL) early response-to-therapy prediction is metabolically assessed by (18)F-FDG PET carrying an excellent negative predictive value (NPV) but an impaired positive predictive value (PPV). Aim of this study was to improve the PPV while keeping the optimal NPV. A comparison of different PET data analyses was performed applying individualized standardized uptake values (SUV), PET-derived metabolic tumor volume (MTV) and the product of both parameters, termed total lesion glycolysis (TLG); Methods: One-hundred-eight PET datasets (PET1, n = 54; PET2, n = 54) of 54 children were analysed by visual and semi-quantitative means. SUVmax, SUVmean, MTV and TLG were obtained the results of both PETs and the relative change from PET1 to PET2 (Δ in %) were compared for their capability of identifying responders and non-responders using receiver operating characteristics (ROC)-curves. In consideration of individual variations in noise and contrasts levels all parameters were additionally obtained after threshold correction to lean body mass and background; Results: All semi-quantitative SUV estimates obtained at PET2 were significantly superior to the visual PET2 analysis. However, ΔSUVmax revealed the best results (area under the curve, 0.92; p < 0.001; sensitivity 100%; specificity 85.4%; PPV 46.2%; NPV 100%; accuracy, 87.0%) but was not significantly superior to SUVmax-estimation at PET2 and ΔTLGmax. Likewise, the lean body mass and background individualization of the datasets did not impove the results of the ROC analyses; Conclusions: Sophisticated semi-quantitative PET measures in early response assessment of pHL patients do not perform significantly better than the previously proposed ΔSUVmax. All analytical strategies failed to improve the impaired PPV to a clinically acceptable level while preserving the excellent NPV.
LB  - PUB:(DE-HGF)16
C6  - pmid:25635760
UR  - <Go to ISI:>//WOS:000209951000010
DO  - DOI:10.3390/cancers7010287
UR  - https://juser.fz-juelich.de/record/817964
ER  -