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000818218 0247_ $$2doi$$a10.1111/acps.12573
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000818218 0247_ $$2ISSN$$a0065-1591
000818218 0247_ $$2ISSN$$a1600-0447
000818218 0247_ $$2ISSN$$a1600-5473
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000818218 041__ $$aEnglish
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000818218 1001_ $$0P:(DE-HGF)0$$aBiskup, C. S.$$b0
000818218 245__ $$aResting state default mode network connectivity in children and adolescents with ADHD after acute tryptophan depletion
000818218 260__ $$aOxford [u. a.]$$bWiley-Blackwell$$c2016
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000818218 520__ $$aObjectiveAlterations of the default mode network (DMN) have been described in patients with neuropsychiatric disorders, including attention deficit hyperactivity disorder (ADHD), and the neurotransmitter serotonin (5-HT) is known to modulate DMN activity. This study aimed to explore the role of 5-HT on the DMN and its functional connectivity (FC) in young patients with ADHD.MethodsYoung male patients with ADHD (n = 12) and healthy controls (n = 10) (both aged 12–17 years) were subjected to acute tryptophan depletion (ATD) and subsequently diminished brain 5-HT synthesis. Three hours after challenge intake (ATD or a balanced control condition, BAL), resting state fMRI scans were obtained.ResultsIn patients, ATD led to attenuated FC of the right superior premotor cortex (BA 6) with the DMN, comparable to the extent found in controls after BAL administration. ATD lowered FC of the left somatosensory cortex (BA 3) with the DMN, independently of the factor group, but with stronger effects in controls.ConclusionsData reveal a serotonergic modulation of FC between BA 6 and 3, known to be relevant for motor planning and sensory perception, and the DMN, thereby possibly pointing toward ATD acting beneficially on neural planning of motor activity in patients with ADHD.
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000818218 7001_ $$0P:(DE-HGF)0$$aHelmbold, K.$$b1
000818218 7001_ $$0P:(DE-HGF)0$$aBaurmann, D.$$b2
000818218 7001_ $$0P:(DE-HGF)0$$aKlasen, M.$$b3
000818218 7001_ $$0P:(DE-HGF)0$$aGaber, T. J.$$b4
000818218 7001_ $$0P:(DE-HGF)0$$aBubenzer-Busch, S.$$b5
000818218 7001_ $$0P:(DE-HGF)0$$aKönigschulte, W.$$b6
000818218 7001_ $$0P:(DE-Juel1)131720$$aFink, G. R.$$b7
000818218 7001_ $$0P:(DE-HGF)0$$aZepf, F. D.$$b8$$eCorresponding author
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