TY  - JOUR
AU  - Biskup, C. S.
AU  - Helmbold, K.
AU  - Baurmann, D.
AU  - Klasen, M.
AU  - Gaber, T. J.
AU  - Bubenzer-Busch, S.
AU  - Königschulte, W.
AU  - Fink, G. R.
AU  - Zepf, F. D.
TI  - Resting state default mode network connectivity in children and adolescents with ADHD after acute tryptophan depletion
JO  - Acta psychiatrica Scandinavica
VL  - 134
IS  - 2
SN  - 0001-690X
CY  - Oxford [u. a.]
PB  - Wiley-Blackwell
M1  - FZJ-2016-04703
SP  - 161 - 171
PY  - 2016
AB  - ObjectiveAlterations of the default mode network (DMN) have been described in patients with neuropsychiatric disorders, including attention deficit hyperactivity disorder (ADHD), and the neurotransmitter serotonin (5-HT) is known to modulate DMN activity. This study aimed to explore the role of 5-HT on the DMN and its functional connectivity (FC) in young patients with ADHD.MethodsYoung male patients with ADHD (n = 12) and healthy controls (n = 10) (both aged 12–17 years) were subjected to acute tryptophan depletion (ATD) and subsequently diminished brain 5-HT synthesis. Three hours after challenge intake (ATD or a balanced control condition, BAL), resting state fMRI scans were obtained.ResultsIn patients, ATD led to attenuated FC of the right superior premotor cortex (BA 6) with the DMN, comparable to the extent found in controls after BAL administration. ATD lowered FC of the left somatosensory cortex (BA 3) with the DMN, independently of the factor group, but with stronger effects in controls.ConclusionsData reveal a serotonergic modulation of FC between BA 6 and 3, known to be relevant for motor planning and sensory perception, and the DMN, thereby possibly pointing toward ATD acting beneficially on neural planning of motor activity in patients with ADHD.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000381688700008
C6  - pmid:27145324
DO  - DOI:10.1111/acps.12573
UR  - https://juser.fz-juelich.de/record/818218
ER  -