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@ARTICLE{Biskup:818218,
      author       = {Biskup, C. S. and Helmbold, K. and Baurmann, D. and Klasen,
                      M. and Gaber, T. J. and Bubenzer-Busch, S. and
                      Königschulte, W. and Fink, G. R. and Zepf, F. D.},
      title        = {{R}esting state default mode network connectivity in
                      children and adolescents with {ADHD} after acute tryptophan
                      depletion},
      journal      = {Acta psychiatrica Scandinavica},
      volume       = {134},
      number       = {2},
      issn         = {0001-690X},
      address      = {Oxford [u. a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {FZJ-2016-04703},
      pages        = {161 - 171},
      year         = {2016},
      abstract     = {ObjectiveAlterations of the default mode network (DMN) have
                      been described in patients with neuropsychiatric disorders,
                      including attention deficit hyperactivity disorder (ADHD),
                      and the neurotransmitter serotonin (5-HT) is known to
                      modulate DMN activity. This study aimed to explore the role
                      of 5-HT on the DMN and its functional connectivity (FC) in
                      young patients with ADHD.MethodsYoung male patients with
                      ADHD (n = 12) and healthy controls (n = 10) (both aged
                      12–17 years) were subjected to acute tryptophan depletion
                      (ATD) and subsequently diminished brain 5-HT synthesis.
                      Three hours after challenge intake (ATD or a balanced
                      control condition, BAL), resting state fMRI scans were
                      obtained.ResultsIn patients, ATD led to attenuated FC of the
                      right superior premotor cortex (BA 6) with the DMN,
                      comparable to the extent found in controls after BAL
                      administration. ATD lowered FC of the left somatosensory
                      cortex (BA 3) with the DMN, independently of the factor
                      group, but with stronger effects in controls.ConclusionsData
                      reveal a serotonergic modulation of FC between BA 6 and 3,
                      known to be relevant for motor planning and sensory
                      perception, and the DMN, thereby possibly pointing toward
                      ATD acting beneficially on neural planning of motor activity
                      in patients with ADHD.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000381688700008},
      pubmed       = {pmid:27145324},
      doi          = {10.1111/acps.12573},
      url          = {https://juser.fz-juelich.de/record/818218},
}