% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Zhu:818252,
      author       = {Zhu, Geng and Du, Liping and Jin, Lei and Offenhäusser,
                      Andreas},
      title        = {{E}ffects of {M}orphology {C}onstraint on
                      {E}lectrophysiological {P}roperties of {C}ortical {N}eurons},
      journal      = {Scientific reports},
      volume       = {6},
      issn         = {2045-2322},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {FZJ-2016-04730},
      pages        = {23086},
      year         = {2016},
      abstract     = {There is growing interest in engineering nerve cells in
                      vitro to control architecture and connectivity of cultured
                      neuronal networks or to build neuronal networks with
                      predictable computational function. Pattern technologies,
                      such as micro-contact printing, have been developed to
                      design ordered neuronal networks. However,
                      electrophysiological characteristics of the single patterned
                      neuron haven’t been reported. Here, micro-contact
                      printing, using polyolefine polymer (POP) stamps with high
                      resolution, was employed to grow cortical neurons in a
                      designed structure. The results demonstrated that the
                      morphology of patterned neurons was well constrained, and
                      the number of dendrites was decreased to be about 2. Our
                      electrophysiological results showed that alterations of
                      dendritic morphology affected firing patterns of neurons and
                      neural excitability. When stimulated by current, though both
                      patterned and un-patterned neurons presented regular
                      spiking, the dynamics and strength of the response were
                      different. The un-patterned neurons exhibited a
                      monotonically increasing firing frequency in response to
                      injected current, while the patterned neurons first
                      exhibited frequency increase and then a slow decrease. Our
                      findings indicate that the decrease in dendritic complexity
                      of cortical neurons will influence their
                      electrophysiological characteristics and alter their
                      information processing activity, which could be considered
                      when designing neuronal circuitries.},
      cin          = {ICS-8},
      ddc          = {000},
      cid          = {I:(DE-Juel1)ICS-8-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000373566700001},
      doi          = {10.1038/srep23086},
      url          = {https://juser.fz-juelich.de/record/818252},
}