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@ARTICLE{Horowitz:818349,
      author       = {Horowitz, Scott and Koepnick, Brian and Martin, Raoul and
                      Tymieniecki, Agnes and Winburn, Amanda A. and Cooper, Seth
                      and Flatten, Jeff and Rogawski, David S. and Koropatkin,
                      Nicole M. and Hailu, Tsinatkeab T. and Jain, Neha and
                      Koldewey, Philipp and Ahlstrom, Logan S. and Chapman,
                      Matthew R. and Sikkema, Andrew P. and Skiba, Meredith A. and
                      Maloney, Finn P. and Beinlich, Felix and Caglar, Ahmet and
                      Coral, Alan and Jensen, Alice Elizabeth and Lubow, Allen and
                      Boitano, Amanda and Lisle, Amy Elizabeth and Maxwell, Andrew
                      T. and Failer, Barb and Kaszubowski, Bartosz and Hrytsiv,
                      Bohdan and Vincenzo, Brancaccio and de Melo Cruz, Breno
                      Renan and McManus, Brian Joseph and Kestemont, Bruno and
                      Vardeman, Carl and Comisky, Casey and Neilson, Catherine and
                      Landers, Catherine R. and Ince, Christopher and Buske,
                      Daniel Jon and Totonjian, Daniel and Copeland, David
                      Marshall and Murray, David and Jagieła, Dawid and Janz,
                      Dietmar and Wheeler, Douglas C. and Cali, Elie and Croze,
                      Emmanuel and Rezae, Farah and Martin, Floyd Orville and
                      Beecher, Gil and de Jong, Guido Alexander and Ykman, Guy and
                      Feldmann, Harald and Chan, Hugo Paul Perez and Kovanecz,
                      Istvan and Vasilchenko, Ivan and Connellan, James C. and
                      Borman, Jami Lynne and Norrgard, Jane and Kanfer, Jebbie and
                      Canfield, Jeffrey M. and Slone, Jesse David and Oh, Jimmy
                      and Mitchell, Joanne and Bishop, John and Kroeger, John
                      Douglas and Schinkler, Jonas and McLaughlin, Joseph and
                      Brownlee, June M. and Bell, Justin and Fellbaum, Karl Willem
                      and Harper, Kathleen and Abbey, Kirk J. and Isaksson,
                      Lennart E. and Wei, Linda and Cummins, Lisa N. and Miller,
                      Lori Anne and Bain, Lyn and Carpenter, Lynn and Desnouck,
                      Maarten and Sharma, Manasa G. and Belcastro, Marcus and
                      Szew, Martin and Szew, Martin and Britton, Matthew and
                      Gaebel, Matthias and Power, Max and Cassidy, Michael and
                      Pfützenreuter, Michael and Minett, Michele and Wesselingh,
                      Michiel and Yi, Minjune and Cameron, Neil Haydn Tormey and
                      Bolibruch, Nicholas I. and Benevides, Noah and Kathleen
                      Kerr, Norah and Barlow, Nova and Crevits, Nykole Krystyne
                      and Dunn, Paul and Silveira Belo Nascimento Roque, Paulo
                      Sergio and Riber, Peter and Pikkanen, Petri and Shehzad,
                      Raafay and Viosca, Randy and James Fraser, Robert and Leduc,
                      Robert and Madala, Roman and Shnider, Scott and de
                      Boisblanc, Sharon and Butkovich, Slava and Bliven, Spencer
                      and Hettler, Stephen and Telehany, Stephen and Schwegmann,
                      Steven A. and Parkes, Steven and Kleinfelter, Susan C. and
                      Michael Holst, Sven and van der Laan, T. J. A. and
                      Bausewein, Thomas and Simon, Vera and Pulley, Warwick and
                      Hull, William and Kim, Annes Yukyung and Lawton, Alexis and
                      Ruesch, Amanda and Sundar, Anjali and Lawrence, Anna-Lisa
                      and Afrin, Antara and Maheshwer, Bhargavi and Turfe, Bilal
                      and Huebner, Christian and Killeen, Courtney Elizabeth and
                      Antebi-Lerrman, Dalia and Luan, Danny and Wolfe, Derek and
                      Pham, Duc and Michewicz, Elaina and Hull, Elizabeth and
                      Pardington, Emily and Galal, Galal Osama and Sun, Grace and
                      Chen, Grace and Anderson, Halie E. and Chang, Jane and
                      Hewlett, Jeffrey Thomas and Sterbenz, Jennifer and Lim, Jiho
                      and Morof, Joshua and Lee, Junho and Inn, Juyoung Samuel and
                      Hahm, Kaitlin and Roth, Kaitlin and Nair, Karun and Markin,
                      Katherine and Schramm, Katie and Toni Eid, Kevin and Gam,
                      Kristina and Murphy, Lisha and Yuan, Lucy and Kana, Lulia
                      and Daboul, Lynn and Shammas, Mario Karam and Chason, Max
                      and Sinan, Moaz and Andrew Tooley, Nicholas and Korakavi,
                      Nisha and Comer, Patrick and Magur, Pragya and Savliwala,
                      Quresh and Davison, Reid Michael and Sankaran, Roshun Rajiv
                      and Lewe, Sam and Tamkus, Saule and Chen, Shirley and
                      Harvey, Sho and Hwang, Sin Ye and Vatsia, Sohrab and
                      Withrow, Stefan and Luther, Tahra K and Manett, Taylor and
                      Johnson, Thomas James and Ryan Brash, Timothy and Kuhlman,
                      Wyatt and Park, Yeonjung and Popović, Zoran and Baker,
                      David and Khatib, Firas and Bardwell, James C. A.},
      title        = {{D}etermining crystal structures through crowdsourcing and
                      coursework},
      journal      = {Nature Communications},
      volume       = {7},
      issn         = {2041-1723},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {FZJ-2016-04815},
      pages        = {12549 -},
      year         = {2016},
      abstract     = {We show here that computer game players can build
                      high-quality crystal structures. Introduction of a new
                      feature into the computer game Foldit allows players to
                      build and real-space refine structures into electron density
                      maps. To assess the usefulness of this feature, we held a
                      crystallographic model-building competition between trained
                      crystallographers, undergraduate students, Foldit players
                      and automatic model-building algorithms. After removal of
                      disordered residues, a team of Foldit players achieved the
                      most accurate structure. Analysing the target protein of the
                      competition, YPL067C, uncovered a new family of histidine
                      triad proteins apparently involved in the prevention of
                      amyloid toxicity. From this study, we conclude that
                      crystallographers can utilize crowdsourcing to interpret
                      electron density information and to produce structure
                      solutions of the highest quality.},
      cin          = {ICS-4},
      ddc          = {500},
      cid          = {I:(DE-Juel1)ICS-4-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000385255200001},
      pubmed       = {pmid:27633552},
      doi          = {10.1038/ncomms12549},
      url          = {https://juser.fz-juelich.de/record/818349},
}