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@ARTICLE{Zeitler:819316,
      author       = {Zeitler, Magteld and Tass, Peter A.},
      title        = {{A}nti-kindling {I}nduced by {T}wo-{S}tage {C}oordinated
                      {R}eset {S}timulation with {W}eak {O}nset {I}ntensity},
      journal      = {Frontiers in computational neuroscience},
      volume       = {10},
      issn         = {1662-5188},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2016-05017},
      pages        = {44},
      year         = {2016},
      abstract     = {Abnormal neuronal synchrony plays an important role in a
                      number of brain diseases. To specifically counteract
                      abnormal neuronal synchrony by desynchronization,
                      Coordinated Reset (CR) stimulation, a spatiotemporally
                      patterned stimulation technique, was designed with
                      computational means. In neuronal networks with spike
                      timing–dependent plasticity CR stimulation causes a
                      decrease of synaptic weights and finally anti-kindling,
                      i.e., unlearning of abnormally strong synaptic connectivity
                      and abnormal neuronal synchrony. Long-lasting
                      desynchronizing aftereffects of CR stimulation have been
                      verified in pre-clinical and clinical proof of concept
                      studies. In general, for different neuromodulation
                      approaches, both invasive and non-invasive, it is desirable
                      to enable effective stimulation at reduced stimulation
                      intensities, thereby avoiding side effects. For the first
                      time, we here present a two-stage CR stimulation protocol,
                      where two qualitatively different types of CR stimulation
                      are delivered one after another, and the first stage comes
                      at a particularly weak stimulation intensity. Numerical
                      simulations show that a two-stage CR stimulation can induce
                      the same degree of anti-kindling as a single-stage CR
                      stimulation with intermediate stimulation intensity. This
                      stimulation approach might be clinically beneficial in
                      patients suffering from brain diseases characterized by
                      abnormal neuronal synchrony where a first treatment stage
                      should be performed at particularly weak stimulation
                      intensities in order to avoid side effects. This might,
                      e.g., be relevant in the context of acoustic CR stimulation
                      in tinnitus patients with hyperacusis or in the case of
                      electrical deep brain CR stimulation with sub-optimally
                      positioned leads or side effects caused by stimulation of
                      the target itself. We discuss how to apply our method in
                      first in man and proof of concept studies.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571) / 899 - ohne
                      Topic (POF3-899)},
      pid          = {G:(DE-HGF)POF3-571 / G:(DE-HGF)POF3-899},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000375840700001},
      pubmed       = {pmid:27242500},
      doi          = {10.3389/fncom.2016.00044},
      url          = {https://juser.fz-juelich.de/record/819316},
}