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@ARTICLE{Tang:819328,
      author       = {Tang, Yunqing and Hendriks, Johnny and Gensch, Thomas and
                      Dai, Luru and Li, Junbai},
      title        = {{A}utomatic {B}ayesian single molecule identification for
                      localization microscopy},
      journal      = {Scientific reports},
      volume       = {6},
      issn         = {2045-2322},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {FZJ-2016-05027},
      pages        = {33521 -},
      year         = {2016},
      abstract     = {Single molecule localization microscopy (SMLM) is on its
                      way to become a mainstream imaging technique in the life
                      sciences. However, analysis of SMLM data is biased by user
                      provided subjective parameters required by the analysis
                      software. To remove this human bias we introduce here the
                      Auto-Bayes method that executes the analysis of SMLM data
                      automatically. We demonstrate the success of the method
                      using the photoelectron count of an emitter as selection
                      characteristic. Moreover, the principle can be used for any
                      characteristic that is bimodally distributed with respect to
                      false and true emitters. The method also allows generation
                      of an emitter reliability map for estimating quality of
                      SMLM-based structures. The potential of the Auto-Bayes
                      method is shown by the fact that our first basic
                      implementation was able to outperform all software packages
                      that were compared in the ISBI online challenge in 2015,
                      with respect to molecule detection (Jaccard index).},
      cin          = {ICS-4},
      ddc          = {000},
      cid          = {I:(DE-Juel1)ICS-4-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000383385300001},
      pubmed       = {pmid:27641933},
      doi          = {10.1038/srep33521},
      url          = {https://juser.fz-juelich.de/record/819328},
}