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@ARTICLE{Barz:819511,
      author       = {Barz, Bogdan and Strodel, Birgit},
      title        = {{U}nderstanding {A}myloid-β {O}ligomerization at the
                      {M}olecular {L}evel: {T}he {R}ole of the {F}ibril {S}urface},
      journal      = {Chemistry - a European journal},
      volume       = {22},
      number       = {26},
      issn         = {0947-6539},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {FZJ-2016-05154},
      pages        = {8768 - 8772},
      year         = {2016},
      abstract     = {The aggregation of the amyloid β-peptide into fibrils is a
                      complex process that involves mechanisms such as primary and
                      secondary nucleation, fibril elongation and fibril
                      fragmentation. Some of these processes generate neurotoxic
                      Aβ oligomers, which are involved in the development of
                      Alzheimer's disease. Recent experimental studies have
                      emphasized the role of the fibril as a catalytic surface for
                      the production of highly toxic oligomers during secondary
                      nucleation. By using molecular dynamics simulations, we show
                      that it is the hydrophobic fibril region that causes the
                      structural changes required for catalyzing the formation of
                      β-sheet-rich Aβ1-42 oligomers on the fibril surface. These
                      results reveal, for the first time, the molecular basis of
                      the secondary nucleation pathway.},
      cin          = {ICS-6},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {553 - Physical Basis of Diseases (POF3-553)},
      pid          = {G:(DE-HGF)POF3-553},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000380270500009},
      pubmed       = {pmid:27135646},
      doi          = {10.1002/chem.201601701},
      url          = {https://juser.fz-juelich.de/record/819511},
}