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@MISC{Kreysing:819577,
      author       = {Kreysing, Eva},
      title        = {{P}oster {A}ward "{S}urface {P}lasmon {R}esonance
                      {M}icroscopy of the {C}ell-{C}hip {I}nterface"},
      address      = {Germany},
      publisher    = {German Biophysics Society},
      reportid     = {FZJ-2016-05207},
      year         = {2016},
      abstract     = {Poster: "Surface Plasmon Resonance Microscopy of the
                      Cell-Chip Interface"Longterm investigation of neuronal
                      networks require non-invasive recordings of the electrical
                      signals. A good coupling between the biological and
                      electronic system is crucial and depends particularly upon
                      the cell-chip distance. The cell-chip distance is an
                      important parameter towards a good sealing, with closer
                      contact leading to a decreased signal dissipation in the
                      cell-electrode cleft. We therefore try to optimize the
                      contact geometry of said interface using protein and lipid
                      coatings. In order to measure the distances between the cell
                      membrane and the chip surface in vitro, we built a surface
                      plasmon resonance microscope (SPRM). With gold coated
                      sapphire chips as the substrate for the cell culture, it is
                      possible to excite plasmons (collective electron
                      oscillations) in the gold layer by illuminating it under a
                      specific angle. The resonance frequency of the plasmons
                      depends strongly upon the dielectric constant of the gold's
                      environment. In turn the angle spectrum of the reflected
                      light depends upon said resonance frequencies. Due to these
                      dependencies it is possible to deduce the cell-substrate
                      distance.Our microscope is capable of imaging the interface
                      in two different modes. The field of view in the live
                      imaging mode is around 65 um x 65 um.This is useful for
                      determining the region of interest for the scanning mode.
                      This mode uses localized surface plasmons to measure the
                      cell-substrate distance. The resolution in z-direction lies
                      in the nanometer range. This allows us to accurately
                      characterize the cell-chip interface.Since SPRM is
                      non-invasive and label free it is suited for longterm
                      investigations.It is therefore possible to observe the
                      development of neuronal networks over several week.},
      cin          = {ICS-8},
      cid          = {I:(DE-Juel1)ICS-8-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)38},
      url          = {https://juser.fz-juelich.de/record/819577},
}