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000819675 1001_ $$0P:(DE-HGF)0$$aAcampora, Federica$$b0
000819675 245__ $$aLipooligosaccharides as Amphiphiles to Build Liposomes for Effective Drug Delivery: The Case of Anticancer Ruthenium Complex-Based Aggregates
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000819675 520__ $$aLiposomes are complex aggregates, often including polyethylene glycol (PEG) to expand their life span in vivo, although their full biocompatibility is still questioned. With the aim to suitably replace PEG within liposomal formulations, here we propose a new liposomes formulation, which includes an amphiphilic molecule of natural origin: the lipooligosaccharide (LOS) from the Gram-negative bacterium Rhizobium rubi. LOS architecture is bifunctional: the lipid moiety at one terminus promotes its insertion into the liposome, the other terminus is hydrophilic and in this case presents an oligosaccharide motif similar to the human Lewis B antigen. Liposomes were prepared by co-formulating de-O-acylated LOS (de-LOS) with the lipid 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and the anticancer nucleolipid-based Ru(III) complex, ToThyRu. In-depth microstructural characterization shows that de-LOS containing liposomes are stable aggregates. In vitro preliminary bioscreens have disclosed their negligible toxic profile and a good uptake in MCF-7 and HaCaT cells. The results validate the use of lipooligosaccharides in formulating liposomes and pave the way to their use in drug delivery applications.
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000819675 65017 $$0V:(DE-MLZ)GC-1602-2016$$2V:(DE-HGF)$$aPolymers, Soft Nano Particles and  Proteins$$x0
000819675 693__ $$0EXP:(DE-MLZ)KWS2-20140101$$1EXP:(DE-MLZ)FRMII-20140101$$5EXP:(DE-MLZ)KWS2-20140101$$6EXP:(DE-MLZ)NL3ao-20140101$$aForschungs-Neutronenquelle Heinz Maier-Leibnitz $$eKWS-2: Small angle scattering diffractometer$$fNL3ao$$x0
000819675 7001_ $$0P:(DE-HGF)0$$aMarzaioli, Alberto Maria$$b1
000819675 7001_ $$0P:(DE-HGF)0$$aCapuozzo, Antonella$$b2
000819675 7001_ $$0P:(DE-Juel1)130507$$aAppavou, Marie-Sousai$$b3$$ufzj
000819675 7001_ $$0P:(DE-Juel1)157777$$aCampanella, Antonella$$b4$$ufzj
000819675 7001_ $$0P:(DE-HGF)0$$aD'Errico, Gerardino$$b5
000819675 7001_ $$0P:(DE-HGF)0$$aIrace, Carlo$$b6
000819675 7001_ $$0P:(DE-HGF)0$$aMontesarchio, Daniela$$b7
000819675 7001_ $$0P:(DE-HGF)0$$aMusumeci, Domenica$$b8
000819675 7001_ $$0P:(DE-Juel1)145431$$aSzekely, Noemi$$b9$$ufzj
000819675 7001_ $$0P:(DE-HGF)0$$aSantamaria, Rita$$b10
000819675 7001_ $$0P:(DE-HGF)0$$aDeCastro, Cristina$$b11$$eCorresponding author
000819675 7001_ $$0P:(DE-HGF)0$$aPaduano, Luigi$$b12$$eCorresponding author
000819675 773__ $$0PERI:(DE-600)2844262-3$$a10.1002/slct.201600255$$gVol. 1, no. 10, p. 2129 - 2139$$n10$$p2129 - 2139$$tChemistrySelect$$v1$$x2365-6549$$y2016
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