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@ARTICLE{Acampora:819675,
      author       = {Acampora, Federica and Marzaioli, Alberto Maria and
                      Capuozzo, Antonella and Appavou, Marie-Sousai and
                      Campanella, Antonella and D'Errico, Gerardino and Irace,
                      Carlo and Montesarchio, Daniela and Musumeci, Domenica and
                      Szekely, Noemi and Santamaria, Rita and DeCastro, Cristina
                      and Paduano, Luigi},
      title        = {{L}ipooligosaccharides as {A}mphiphiles to {B}uild
                      {L}iposomes for {E}ffective {D}rug {D}elivery: {T}he {C}ase
                      of {A}nticancer {R}uthenium {C}omplex-{B}ased {A}ggregates},
      journal      = {ChemistrySelect},
      volume       = {1},
      number       = {10},
      issn         = {2365-6549},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {FZJ-2016-05282},
      pages        = {2129 - 2139},
      year         = {2016},
      abstract     = {Liposomes are complex aggregates, often including
                      polyethylene glycol (PEG) to expand their life span
                      in vivo, although their full biocompatibility is still
                      questioned. With the aim to suitably replace PEG within
                      liposomal formulations, here we propose a new liposomes
                      formulation, which includes an amphiphilic molecule of
                      natural origin: the lipooligosaccharide (LOS) from the
                      Gram-negative bacterium Rhizobium rubi. LOS architecture is
                      bifunctional: the lipid moiety at one terminus promotes its
                      insertion into the liposome, the other terminus is
                      hydrophilic and in this case presents an oligosaccharide
                      motif similar to the human Lewis B antigen. Liposomes were
                      prepared by co-formulating de-O-acylated LOS (de-LOS) with
                      the lipid 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine
                      (POPC) and the anticancer nucleolipid-based Ru(III) complex,
                      ToThyRu. In-depth microstructural characterization shows
                      that de-LOS containing liposomes are stable aggregates. In
                      vitro preliminary bioscreens have disclosed their negligible
                      toxic profile and a good uptake in MCF-7 and HaCaT cells.
                      The results validate the use of lipooligosaccharides in
                      formulating liposomes and pave the way to their use in drug
                      delivery applications.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {6G15 - FRM II / MLZ (POF3-6G15) / 6G4 - Jülich Centre for
                      Neutron Research (JCNS) (POF3-623)},
      pid          = {G:(DE-HGF)POF3-6G15 / G:(DE-HGF)POF3-6G4},
      experiment   = {EXP:(DE-MLZ)KWS2-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000395417800006},
      doi          = {10.1002/slct.201600255},
      url          = {https://juser.fz-juelich.de/record/819675},
}