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000819795 1001_ $$0P:(DE-HGF)0$$aDaletos, Georgios$$b0
000819795 245__ $$aCallyaerins from the Marine Sponge Callyspongia aerizusa : Cyclic Peptides with Antitubercular Activity
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000819795 520__ $$aChemical investigation of the Indonesian sponge Callyspongia aerizusa afforded five new cyclic peptides, callyaerins I−M (1−5), along with the known callyaerins A−G (6−12). The structures of the new compounds were unambiguously elucidated on the basis of one- and twodimensional NMR spectroscopy and mass spectrometry. In addition, the structures of callyaerins D (9), F (11), and G (12), previously available in only small amounts, have been reinvestigated and revised. All compounds were tested in vitro against Mycobacterium tuberculosis, as well as against THP-1 (human acute monocytic leukemia) and MRC-5 (human fetal lung fibroblast) cell lines, in order to assess their general cytotoxicity. Callyaerins A (6) and B (7) showed potent anti-TB activity with MIC90 values of 2 and 5 μM, respectively. Callyaerin C (8) was found to be less active, with an MIC90 value of 40 μM. Callyaerin A (6), which showed the strongest anti- TB activity, was not cytotoxic to THP-1 or MRC-5 cells (IC50 > 10 μM), which highlights the potential of these compounds as promising anti-TB agents.
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000819795 7001_ $$0P:(DE-HGF)0$$aKalscheuer, Rainer$$b1
000819795 7001_ $$0P:(DE-HGF)0$$aKoliwer-Brandl, Hendrik$$b2
000819795 7001_ $$0P:(DE-Juel1)132001$$aHartmann, Rudolf$$b3$$ufzj
000819795 7001_ $$0P:(DE-HGF)0$$ade Voogd, Nicole J.$$b4
000819795 7001_ $$0P:(DE-HGF)0$$aWray, Victor$$b5
000819795 7001_ $$0P:(DE-HGF)0$$aLin, Wenhan$$b6
000819795 7001_ $$0P:(DE-HGF)0$$aProksch, Peter$$b7$$eCorresponding author
000819795 773__ $$0PERI:(DE-600)1491522-4$$a10.1021/acs.jnatprod.5b00266$$gVol. 78, no. 8, p. 1910 - 1925$$n8$$p1910 - 1925$$tJournal of natural products$$v78$$x1520-6025$$y2015
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