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@ARTICLE{Daletos:819795,
      author       = {Daletos, Georgios and Kalscheuer, Rainer and
                      Koliwer-Brandl, Hendrik and Hartmann, Rudolf and de Voogd,
                      Nicole J. and Wray, Victor and Lin, Wenhan and Proksch,
                      Peter},
      title        = {{C}allyaerins from the {M}arine {S}ponge {C}allyspongia
                      aerizusa : {C}yclic {P}eptides with {A}ntitubercular
                      {A}ctivity},
      journal      = {Journal of natural products},
      volume       = {78},
      number       = {8},
      issn         = {1520-6025},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {FZJ-2016-05390},
      pages        = {1910 - 1925},
      year         = {2015},
      abstract     = {Chemical investigation of the Indonesian sponge
                      Callyspongia aerizusa afforded five new cyclic peptides,
                      callyaerins I−M (1−5), along with the known callyaerins
                      A−G (6−12). The structures of the new compounds were
                      unambiguously elucidated on the basis of one- and
                      twodimensional NMR spectroscopy and mass spectrometry. In
                      addition, the structures of callyaerins D (9), F (11), and G
                      (12), previously available in only small amounts, have been
                      reinvestigated and revised. All compounds were tested in
                      vitro against Mycobacterium tuberculosis, as well as against
                      THP-1 (human acute monocytic leukemia) and MRC-5 (human
                      fetal lung fibroblast) cell lines, in order to assess their
                      general cytotoxicity. Callyaerins A (6) and B (7) showed
                      potent anti-TB activity with MIC90 values of 2 and 5 μM,
                      respectively. Callyaerin C (8) was found to be less active,
                      with an MIC90 value of 40 μM. Callyaerin A (6), which
                      showed the strongest anti- TB activity, was not cytotoxic to
                      THP-1 or MRC-5 cells (IC50 > 10 μM), which highlights the
                      potential of these compounds as promising anti-TB agents.},
      cin          = {ICS-6},
      ddc          = {500},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {553 - Physical Basis of Diseases (POF3-553)},
      pid          = {G:(DE-HGF)POF3-553},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000360773700014},
      pubmed       = {pmid:26213786},
      doi          = {10.1021/acs.jnatprod.5b00266},
      url          = {https://juser.fz-juelich.de/record/819795},
}