%0 Journal Article
%A AlTarabeen, Mousa
%A Daletos, Georgios
%A Ebrahim, Weaam
%A Müller, Werner E. G.
%A Hartmann, Rudolf
%A Lin, Wehan
%A Proksch, Peter
%T Ircinal E, a New Manzamine Derivative frim the Indonesian Marine Sponge Acanthostrongylophora ingens
%J Natural product communications
%V 10
%@ 1555-9475
%C Westerville, Ohio
%I NPC
%M FZJ-2016-05391
%P 1951-1953
%D 2015
%X Chemical investigation of the MeOH extract of the sponge Acanthostrongylophora ingens afforded the new manzamine derivative ircinal E (1), in addition tosix known metabolites (2–7). The structure of the new compound was unequivocally elucidated using one- and two-dimensional NMR spectroscopy, as wellas high-resolution mass spectrometry. Compounds 1–6 exhibited strong to moderate cytotoxicity against the murine lymphoma L5178Y cell line with IC50values ranging from 2.8 to 21.7 μM.
%F PUB:(DE-HGF)16
%9 Journal Article
%U https://juser.fz-juelich.de/record/819796