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000819796 1001_ $$0P:(DE-HGF)0$$aAlTarabeen, Mousa$$b0
000819796 245__ $$aIrcinal E, a New Manzamine Derivative frim the Indonesian Marine Sponge Acanthostrongylophora ingens
000819796 260__ $$aWesterville, Ohio$$bNPC$$c2015
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000819796 520__ $$aChemical investigation of the MeOH extract of the sponge Acanthostrongylophora ingens afforded the new manzamine derivative ircinal E (1), in addition tosix known metabolites (2–7). The structure of the new compound was unequivocally elucidated using one- and two-dimensional NMR spectroscopy, as wellas high-resolution mass spectrometry. Compounds 1–6 exhibited strong to moderate cytotoxicity against the murine lymphoma L5178Y cell line with IC50values ranging from 2.8 to 21.7 μM.
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000819796 7001_ $$0P:(DE-HGF)0$$aMüller, Werner E. G.$$b3
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000819796 7001_ $$0P:(DE-HGF)0$$aLin, Wehan$$b5
000819796 7001_ $$0P:(DE-HGF)0$$aProksch, Peter$$b6$$eCorresponding author
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