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@ARTICLE{Akone:819802,
      author       = {Akone, Sergi Herve and Mándi, Attila and Kurtán, Tibor
                      and Hartmann, Rudolf and Lin, Wenhan and Daletos, Georgios
                      and Proksch, Peter},
      title        = {{I}nducing secondary metabolite production by the
                      endophytic fungus {C}haetomium sp. through
                      fungal–bacterial co-culture and epigenetic modification},
      journal      = {Tetrahedron},
      volume       = {72},
      number       = {41},
      issn         = {0040-4020},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2016-05397},
      pages        = {6340 - 6347},
      year         = {2016},
      abstract     = {Co-culturing the fungal endophyte Chaetomium sp. with the
                      bacterium Bacillus subtilis on solid rice medium resulted in
                      an up to 8.3-fold increase in the accumulation of
                      constitutively present metabolites that included a 1:1
                      mixture of 3- and 4-hydroxybenzoic acid methyl esters (1 and
                      2, respectively), and the polyketides acremonisol A (3),
                      SB236050 (4), and SB238569 (5). In addition, seven compounds
                      including isosulochrin (6), protocatechuic acid methyl ester
                      (7), as well as five new natural products (8e12) were
                      detected in the co-cultures, but not in axenic fungal
                      cultures. Treatment of Chaetomium sp. with the epigenetic
                      modifier suberoylanilide hydroxamic acid or 5-azacytidine
                      resulted in an enhanced accumulation of 6, which was
                      likewise detected during co-culture. Compound 5 showed
                      strong cytotoxicity against the mouse lymphoma L5178Y cell
                      line with an IC50 value of 1 mM, as well as weak
                      antibacterial activity against B. subtilis with an MIC value
                      of 53 mM.},
      cin          = {ICS-6},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000384776300007},
      doi          = {10.1016/j.tet.2016.08.022},
      url          = {https://juser.fz-juelich.de/record/819802},
}