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| 001 | 819802 | ||
| 005 | 20210129224354.0 | ||
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| 100 | 1 | _ | |a Akone, Sergi Herve |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Inducing secondary metabolite production by the endophytic fungus Chaetomium sp. through fungal–bacterial co-culture and epigenetic modification |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2016 |b Elsevier Science |
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| 520 | _ | _ | |a Co-culturing the fungal endophyte Chaetomium sp. with the bacterium Bacillus subtilis on solid rice medium resulted in an up to 8.3-fold increase in the accumulation of constitutively present metabolites that included a 1:1 mixture of 3- and 4-hydroxybenzoic acid methyl esters (1 and 2, respectively), and the polyketides acremonisol A (3), SB236050 (4), and SB238569 (5). In addition, seven compounds including isosulochrin (6), protocatechuic acid methyl ester (7), as well as five new natural products (8e12) were detected in the co-cultures, but not in axenic fungal cultures. Treatment of Chaetomium sp. with the epigenetic modifier suberoylanilide hydroxamic acid or 5-azacytidine resulted in an enhanced accumulation of 6, which was likewise detected during co-culture. Compound 5 showed strong cytotoxicity against the mouse lymphoma L5178Y cell line with an IC50 value of 1 mM, as well as weak antibacterial activity against B. subtilis with an MIC value of 53 mM. |
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| 700 | 1 | _ | |a Lin, Wenhan |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Daletos, Georgios |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Proksch, Peter |0 P:(DE-HGF)0 |b 6 |e Corresponding author |
| 773 | _ | _ | |a 10.1016/j.tet.2016.08.022 |g Vol. 72, no. 41, p. 6340 - 6347 |0 PERI:(DE-600)2007072-X |n 41 |p 6340 - 6347 |t Tetrahedron |v 72 |y 2016 |x 0040-4020 |
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