000819806 001__ 819806
000819806 005__ 20210129224355.0
000819806 0247_ $$2doi$$a10.1021/acs.jnatprod.6b00473
000819806 0247_ $$2ISSN$$a0163-3864
000819806 0247_ $$2ISSN$$a1520-6025
000819806 0247_ $$2WOS$$aWOS:000384156700024
000819806 0247_ $$2altmetric$$aaltmetric:10814800
000819806 0247_ $$2pmid$$apmid:27556865
000819806 037__ $$aFZJ-2016-05401
000819806 041__ $$aEnglish
000819806 082__ $$a500
000819806 1001_ $$0P:(DE-Juel1)168241$$aLiu, Shuai$$b0$$ufzj
000819806 245__ $$aCytotoxic 14-Membered Macrolides from a Mangrove-Derived Endophytic Fungus, Pestalotiopsis microspora
000819806 260__ $$aWashington, DC$$bSoc.$$c2016
000819806 3367_ $$2DRIVER$$aarticle
000819806 3367_ $$2DataCite$$aOutput Types/Journal article
000819806 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1476769974_28931
000819806 3367_ $$2BibTeX$$aARTICLE
000819806 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000819806 3367_ $$00$$2EndNote$$aJournal Article
000819806 520__ $$aSeven new 14-membered macrolides, pestalotioprolides C (2), D−H (4−8), and 7-O-methylnigrosporolide (3), together with four known analogues, pestalotioprolide B (1), seiricuprolide (9), nigrosporolide (10), and 4,7-dihydroxy-13-tetradeca-2,5,8-trienolide (11), were isolated from the mangrove-derived endophytic fungus Pestalotiopsis microspora. Their structures were elucidated by analysis of NMR and MS data and by comparison with literature data. Single-crystal X-ray diffraction analysis was used to confirm the absolute configurations of 1, 2, and 10, while Mosher’s method and the TDDFT-ECD approach were applied to determine the absolute configurations of 5 and 6. Compounds 3−6 showed significant cytotoxicity against the murine lymphoma cell line L5178Y with IC50 values of 0.7, 5.6, 3.4, and 3.9 μM, respectively, while compound 5 showed potent activity against the human ovarian cancer cell line A2780 with an IC50 value of 1.2 μM. Structure−activity relationships are discussed. Coculture of P. microspora with Streptomyces lividans caused a roughly 10-fold enhanced accumulation of compounds 5 and 6 compared to axenic fungal control.
000819806 536__ $$0G:(DE-HGF)POF3-552$$a552 - Engineering Cell Function (POF3-552)$$cPOF3-552$$fPOF III$$x0
000819806 588__ $$aDataset connected to CrossRef
000819806 7001_ $$0P:(DE-HGF)0$$aDai, Haofu$$b1
000819806 7001_ $$0P:(DE-HGF)0$$aMakhloufi, Gamall$$b2
000819806 7001_ $$0P:(DE-HGF)0$$aHeering, Christian$$b3
000819806 7001_ $$0P:(DE-HGF)0$$aJaniak, Christoph$$b4
000819806 7001_ $$0P:(DE-Juel1)132001$$aHartmann, Rudolf$$b5$$ufzj
000819806 7001_ $$0P:(DE-HGF)0$$aMándi, Attila$$b6
000819806 7001_ $$0P:(DE-HGF)0$$aKurtán, Tibor$$b7
000819806 7001_ $$0P:(DE-HGF)0$$aMüller, Werner E. G.$$b8
000819806 7001_ $$0P:(DE-HGF)0$$aKassack, Matthias U.$$b9
000819806 7001_ $$0P:(DE-HGF)0$$aLin, Wenhan$$b10
000819806 7001_ $$0P:(DE-HGF)0$$aLiu, Zhen$$b11
000819806 7001_ $$0P:(DE-HGF)0$$aProksch, Peter$$b12$$eCorresponding author
000819806 773__ $$0PERI:(DE-600)1491522-4$$a10.1021/acs.jnatprod.6b00473$$gVol. 79, no. 9, p. 2332 - 2340$$n9$$p2332 - 2340$$tJournal of natural products$$v79$$x1520-6025$$y2016
000819806 8564_ $$uhttps://juser.fz-juelich.de/record/819806/files/Cytotoxic%2014-Membered%20Macrolides%20from%20a%20Mangrove-Derived%20Endophytic%20Fungus%2C%20Pestalotiopsis%20microspora_2016.pdf$$yRestricted
000819806 8564_ $$uhttps://juser.fz-juelich.de/record/819806/files/Cytotoxic%2014-Membered%20Macrolides%20from%20a%20Mangrove-Derived%20Endophytic%20Fungus%2C%20Pestalotiopsis%20microspora_2016.gif?subformat=icon$$xicon$$yRestricted
000819806 8564_ $$uhttps://juser.fz-juelich.de/record/819806/files/Cytotoxic%2014-Membered%20Macrolides%20from%20a%20Mangrove-Derived%20Endophytic%20Fungus%2C%20Pestalotiopsis%20microspora_2016.jpg?subformat=icon-1440$$xicon-1440$$yRestricted
000819806 8564_ $$uhttps://juser.fz-juelich.de/record/819806/files/Cytotoxic%2014-Membered%20Macrolides%20from%20a%20Mangrove-Derived%20Endophytic%20Fungus%2C%20Pestalotiopsis%20microspora_2016.jpg?subformat=icon-180$$xicon-180$$yRestricted
000819806 8564_ $$uhttps://juser.fz-juelich.de/record/819806/files/Cytotoxic%2014-Membered%20Macrolides%20from%20a%20Mangrove-Derived%20Endophytic%20Fungus%2C%20Pestalotiopsis%20microspora_2016.jpg?subformat=icon-640$$xicon-640$$yRestricted
000819806 8564_ $$uhttps://juser.fz-juelich.de/record/819806/files/Cytotoxic%2014-Membered%20Macrolides%20from%20a%20Mangrove-Derived%20Endophytic%20Fungus%2C%20Pestalotiopsis%20microspora_2016.pdf?subformat=pdfa$$xpdfa$$yRestricted
000819806 909CO $$ooai:juser.fz-juelich.de:819806$$pVDB
000819806 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)168241$$aForschungszentrum Jülich$$b0$$kFZJ
000819806 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)132001$$aForschungszentrum Jülich$$b5$$kFZJ
000819806 9131_ $$0G:(DE-HGF)POF3-552$$1G:(DE-HGF)POF3-550$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lBioSoft – Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences$$vEngineering Cell Function$$x0
000819806 9141_ $$y2016
000819806 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000819806 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000819806 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record
000819806 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bJ NAT PROD : 2015
000819806 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000819806 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000819806 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000819806 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000819806 915__ $$0StatID:(DE-HGF)0550$$2StatID$$aNo Authors Fulltext
000819806 915__ $$0StatID:(DE-HGF)1060$$2StatID$$aDBCoverage$$bCurrent Contents - Agriculture, Biology and Environmental Sciences
000819806 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000819806 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000819806 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000819806 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000819806 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000819806 920__ $$lyes
000819806 9201_ $$0I:(DE-Juel1)ICS-6-20110106$$kICS-6$$lStrukturbiochemie $$x0
000819806 980__ $$ajournal
000819806 980__ $$aVDB
000819806 980__ $$aUNRESTRICTED
000819806 980__ $$aI:(DE-Juel1)ICS-6-20110106
000819806 981__ $$aI:(DE-Juel1)IBI-7-20200312