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@ARTICLE{Liu:819806,
      author       = {Liu, Shuai and Dai, Haofu and Makhloufi, Gamall and
                      Heering, Christian and Janiak, Christoph and Hartmann,
                      Rudolf and Mándi, Attila and Kurtán, Tibor and Müller,
                      Werner E. G. and Kassack, Matthias U. and Lin, Wenhan and
                      Liu, Zhen and Proksch, Peter},
      title        = {{C}ytotoxic 14-{M}embered {M}acrolides from a
                      {M}angrove-{D}erived {E}ndophytic {F}ungus, {P}estalotiopsis
                      microspora},
      journal      = {Journal of natural products},
      volume       = {79},
      number       = {9},
      issn         = {1520-6025},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {FZJ-2016-05401},
      pages        = {2332 - 2340},
      year         = {2016},
      abstract     = {Seven new 14-membered macrolides, pestalotioprolides C (2),
                      D−H (4−8), and 7-O-methylnigrosporolide (3), together
                      with four known analogues, pestalotioprolide B (1),
                      seiricuprolide (9), nigrosporolide (10), and
                      4,7-dihydroxy-13-tetradeca-2,5,8-trienolide (11), were
                      isolated from the mangrove-derived endophytic fungus
                      Pestalotiopsis microspora. Their structures were elucidated
                      by analysis of NMR and MS data and by comparison with
                      literature data. Single-crystal X-ray diffraction analysis
                      was used to confirm the absolute configurations of 1, 2, and
                      10, while Mosher’s method and the TDDFT-ECD approach were
                      applied to determine the absolute configurations of 5 and 6.
                      Compounds 3−6 showed significant cytotoxicity against the
                      murine lymphoma cell line L5178Y with IC50 values of 0.7,
                      5.6, 3.4, and 3.9 μM, respectively, while compound 5 showed
                      potent activity against the human ovarian cancer cell line
                      A2780 with an IC50 value of 1.2 μM. Structure−activity
                      relationships are discussed. Coculture of P. microspora with
                      Streptomyces lividans caused a roughly 10-fold enhanced
                      accumulation of compounds 5 and 6 compared to axenic fungal
                      control.},
      cin          = {ICS-6},
      ddc          = {500},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000384156700024},
      pubmed       = {pmid:27556865},
      doi          = {10.1021/acs.jnatprod.6b00473},
      url          = {https://juser.fz-juelich.de/record/819806},
}