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@ARTICLE{Viegas:819928,
      author       = {Viegas, Aldino and Viennet, Thibault and Yu, Tsyr-Yan and
                      Schumann, Frank and Bermel, Wolfgang and Wagner, Gerhard and
                      Etzkorn, Manuel},
      title        = {{UTOPIA} {NMR}: activating unexploited magnetization using
                      interleaved low-gamma detection},
      journal      = {Journal of biomolecular NMR},
      volume       = {64},
      number       = {1},
      issn         = {1573-5001},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V},
      reportid     = {FZJ-2016-05502},
      pages        = {9 - 15},
      year         = {2016},
      abstract     = {A growing number of nuclear magnetic resonance (NMR)
                      spectroscopic studies are impaired by the limited
                      information content provided by the standard set of
                      experiments conventionally recorded. This is particularly
                      true for studies of challenging biological systems including
                      large, unstructured, membrane-embedded and/or paramagnetic
                      proteins. Here we introduce the concept of unified
                      time-optimized interleaved acquisition NMR (UTOPIANMR) for
                      the unified acquisition of standard high-c (e.g. 1H) and
                      low-c (e.g. 13C) detected experiments using a single
                      receiver. Our aim is to activate the high level of
                      polarization and information content distributed on low-c
                      nuclei without disturbing conventional magnetization
                      transfer pathways. We show that using UTOPIA-NMR we are able
                      to recover nearly all of the normally non-used magnetization
                      without disturbing the standard experiments. In other words,
                      additional spectra, that can significantly increase the NMR
                      insights, are obtained for free. While we anticipate a broad
                      range of possible applications we demonstrate for the
                      soluble protein Bcl-xL (ca. 21 kDa) and for OmpX in
                      nanodiscs (ca. 160 kDa) that UTOPIA-NMR is particularly
                      useful for challenging protein systems including
                      perdeuterated (membrane) proteins.},
      cin          = {ICS-6},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000372168000002},
      doi          = {10.1007/s10858-015-0008-7},
      url          = {https://juser.fz-juelich.de/record/819928},
}