%0 Journal Article
%A Rabenstein, Monika
%A Vay, Sabine Ulrike
%A Flitsch, Lea Jessica
%A Fink, Gereon Rudolf
%A Schroeter, Michael
%A Rueger, Maria Adele
%T Osteopontin directly modulates cytokine expression of primary microglia and increases their survival
%J Journal of neuroimmunology
%V 299
%@ 0165-5728
%C Amsterdam [u.a.]
%I Elsevier Science
%M FZJ-2016-05654
%P 130 - 138
%D 2016
%X Osteopontin (OPN) is constitutively expressed in the brain and upregulated during neuroinflammation, e.g., focal cerebral ischemia. In OPN-deficient mice, microglia are deregulated after ischemia, but specific OPN-effects on microglia remain elusive.Primary microglia were cultured in the presence or absence of OPN. The survival of microglia under stress conditions was dose-dependently increased by OPN. Lipopolysaccharides (LPS)-induced release of nitric oxide (NO), TNF-α, and IL-6, as well as expression of inducible Nitric Oxide Synthase (iNOS), were attenuated by OPN. Data suggest that OPN modulates microglia function by shifting their inflammatory profile towards a neutral anti-inflammatory phenotype.
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000386190900021
%$ pmid:27725111
%R 10.1016/j.jneuroim.2016.09.009
%U https://juser.fz-juelich.de/record/820103