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000820103 1001_ $$00000-0002-6183-6253$$aRabenstein, Monika$$b0
000820103 245__ $$aOsteopontin directly modulates cytokine expression of primary microglia and increases their survival
000820103 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2016
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000820103 520__ $$aOsteopontin (OPN) is constitutively expressed in the brain and upregulated during neuroinflammation, e.g., focal cerebral ischemia. In OPN-deficient mice, microglia are deregulated after ischemia, but specific OPN-effects on microglia remain elusive.Primary microglia were cultured in the presence or absence of OPN. The survival of microglia under stress conditions was dose-dependently increased by OPN. Lipopolysaccharides (LPS)-induced release of nitric oxide (NO), TNF-α, and IL-6, as well as expression of inducible Nitric Oxide Synthase (iNOS), were attenuated by OPN. Data suggest that OPN modulates microglia function by shifting their inflammatory profile towards a neutral anti-inflammatory phenotype.
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000820103 7001_ $$0P:(DE-HGF)0$$aVay, Sabine Ulrike$$b1
000820103 7001_ $$0P:(DE-HGF)0$$aFlitsch, Lea Jessica$$b2
000820103 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon Rudolf$$b3
000820103 7001_ $$0P:(DE-HGF)0$$aSchroeter, Michael$$b4
000820103 7001_ $$0P:(DE-HGF)0$$aRueger, Maria Adele$$b5$$eCorresponding author
000820103 773__ $$0PERI:(DE-600)1500497-1$$a10.1016/j.jneuroim.2016.09.009$$gVol. 299, p. 130 - 138$$p130 - 138$$tJournal of neuroimmunology$$v299$$x0165-5728$$y2016
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