TY  - JOUR
AU  - Rabenstein, Monika
AU  - Vay, Sabine Ulrike
AU  - Flitsch, Lea Jessica
AU  - Fink, Gereon Rudolf
AU  - Schroeter, Michael
AU  - Rueger, Maria Adele
TI  - Osteopontin directly modulates cytokine expression of primary microglia and increases their survival
JO  - Journal of neuroimmunology
VL  - 299
SN  - 0165-5728
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - FZJ-2016-05654
SP  - 130 - 138
PY  - 2016
AB  - Osteopontin (OPN) is constitutively expressed in the brain and upregulated during neuroinflammation, e.g., focal cerebral ischemia. In OPN-deficient mice, microglia are deregulated after ischemia, but specific OPN-effects on microglia remain elusive.Primary microglia were cultured in the presence or absence of OPN. The survival of microglia under stress conditions was dose-dependently increased by OPN. Lipopolysaccharides (LPS)-induced release of nitric oxide (NO), TNF-α, and IL-6, as well as expression of inducible Nitric Oxide Synthase (iNOS), were attenuated by OPN. Data suggest that OPN modulates microglia function by shifting their inflammatory profile towards a neutral anti-inflammatory phenotype.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000386190900021
C6  - pmid:27725111
DO  - DOI:10.1016/j.jneuroim.2016.09.009
UR  - https://juser.fz-juelich.de/record/820103
ER  -