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@ARTICLE{Rabenstein:820103,
      author       = {Rabenstein, Monika and Vay, Sabine Ulrike and Flitsch, Lea
                      Jessica and Fink, Gereon Rudolf and Schroeter, Michael and
                      Rueger, Maria Adele},
      title        = {{O}steopontin directly modulates cytokine expression of
                      primary microglia and increases their survival},
      journal      = {Journal of neuroimmunology},
      volume       = {299},
      issn         = {0165-5728},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2016-05654},
      pages        = {130 - 138},
      year         = {2016},
      abstract     = {Osteopontin (OPN) is constitutively expressed in the brain
                      and upregulated during neuroinflammation, e.g., focal
                      cerebral ischemia. In OPN-deficient mice, microglia are
                      deregulated after ischemia, but specific OPN-effects on
                      microglia remain elusive.Primary microglia were cultured in
                      the presence or absence of OPN. The survival of microglia
                      under stress conditions was dose-dependently increased by
                      OPN. Lipopolysaccharides (LPS)-induced release of nitric
                      oxide (NO), TNF-α, and IL-6, as well as expression of
                      inducible Nitric Oxide Synthase (iNOS), were attenuated by
                      OPN. Data suggest that OPN modulates microglia function by
                      shifting their inflammatory profile towards a neutral
                      anti-inflammatory phenotype.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000386190900021},
      pubmed       = {pmid:27725111},
      doi          = {10.1016/j.jneuroim.2016.09.009},
      url          = {https://juser.fz-juelich.de/record/820103},
}