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| 001 | 820103 | ||
| 005 | 20210129224445.0 | ||
| 024 | 7 | _ | |a 10.1016/j.jneuroim.2016.09.009 |2 doi |
| 024 | 7 | _ | |a 0165-5728 |2 ISSN |
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| 100 | 1 | _ | |a Rabenstein, Monika |0 0000-0002-6183-6253 |b 0 |
| 245 | _ | _ | |a Osteopontin directly modulates cytokine expression of primary microglia and increases their survival |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2016 |b Elsevier Science |
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| 520 | _ | _ | |a Osteopontin (OPN) is constitutively expressed in the brain and upregulated during neuroinflammation, e.g., focal cerebral ischemia. In OPN-deficient mice, microglia are deregulated after ischemia, but specific OPN-effects on microglia remain elusive.Primary microglia were cultured in the presence or absence of OPN. The survival of microglia under stress conditions was dose-dependently increased by OPN. Lipopolysaccharides (LPS)-induced release of nitric oxide (NO), TNF-α, and IL-6, as well as expression of inducible Nitric Oxide Synthase (iNOS), were attenuated by OPN. Data suggest that OPN modulates microglia function by shifting their inflammatory profile towards a neutral anti-inflammatory phenotype. |
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| 700 | 1 | _ | |a Vay, Sabine Ulrike |0 P:(DE-HGF)0 |b 1 |
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| 700 | 1 | _ | |a Schroeter, Michael |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Rueger, Maria Adele |0 P:(DE-HGF)0 |b 5 |e Corresponding author |
| 773 | _ | _ | |a 10.1016/j.jneuroim.2016.09.009 |g Vol. 299, p. 130 - 138 |0 PERI:(DE-600)1500497-1 |p 130 - 138 |t Journal of neuroimmunology |v 299 |y 2016 |x 0165-5728 |
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