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@ARTICLE{Chen:820383,
      author       = {Chen, La and Li, Wenfang and Maybeck, Vanessa and
                      Offenhäusser, Andreas and Krause, Hans-Joachim},
      title        = {{S}tatistical study of biomechanics of living brain cells
                      during growth and maturation on artificial substrates},
      journal      = {Biomaterials},
      volume       = {106},
      issn         = {0142-9612},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2016-05714},
      pages        = {240 - 249},
      year         = {2016},
      abstract     = {There is increasing evidence that mechanical issues play a
                      vital role in neuron growth and brain development. The
                      importance of this grows as novel devices, whose material
                      properties differ from cells, are increasingly implanted in
                      the body. In this work, we studied the mechanical properties
                      of rat brain cells over time and on different materials by
                      using a high throughput magnetic tweezers system. It was
                      found that the elastic moduli of both neurite and soma in
                      networked neurons increased with growth. However, neurites
                      at DIV4 exhibited a relatively high stiffness, which could
                      be ascribed to the high outgrowth tension. The power-law
                      exponents (viscoelasticity) of both neurites and somas of
                      neurons decreased with culture time. On the other hand, the
                      stiffness of glial cells also increased with maturity.
                      Furthermore, both neurites and glia become softer when
                      cultured on compliant substrates. Especially, the glial
                      cells cultured on a soft substrate obviously showed a less
                      dense and more porous actin and GFAP mesh. In addition, the
                      viscoelasticity of both neurites and glia did not show a
                      significant dependence on the substrates' stiffness.},
      cin          = {ICS-8},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-8-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000383934300020},
      doi          = {10.1016/j.biomaterials.2016.08.029},
      url          = {https://juser.fz-juelich.de/record/820383},
}