% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Henry:820533,
      author       = {Henry, Ewan and Holm, Stefan H. and Zhang, Zunmin and
                      Beech, Jason P. and Tegenfeldt, Jonas O. and Fedosov, Dmitry
                      and Gompper, Gerhard},
      title        = {{S}orting cells by their dynamical properties},
      journal      = {Scientific reports},
      volume       = {6},
      issn         = {2045-2322},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {FZJ-2016-05822},
      pages        = {34375},
      year         = {2016},
      abstract     = {Recent advances in cell sorting aim at the development of
                      novel methods that are sensitive to various mechanical
                      properties of cells. Microfluidic technologies have a great
                      potential for cell sorting; however, the design of many
                      micro-devices is based on theories developed for rigid
                      spherical particles with size as a separation parameter.
                      Clearly, most bioparticles are non-spherical and deformable
                      and therefore exhibit a much more intricate behavior in
                      fluid flow than rigid spheres. Here, we demonstrate the use
                      of cells’ mechanical and dynamical properties as
                      biomarkers for separation by employing a combination of
                      mesoscale hydrodynamic simulations and microfluidic
                      experiments. The dynamic behavior of red blood cells (RBCs)
                      within deterministic lateral displacement (DLD) devices is
                      investigated for different device geometries and viscosity
                      contrasts between the intra-cellular fluid and suspending
                      medium. We find that the viscosity contrast and associated
                      cell dynamics clearly determine the RBC trajectory through a
                      DLD device. Simulation results compare well to experiments
                      and provide new insights into the physical mechanisms which
                      govern the sorting of non-spherical and deformable cells in
                      DLD devices. Finally, we discuss the implications of cell
                      dynamics for sorting schemes based on properties other than
                      cell size, such as mechanics and morphology.},
      cin          = {ICS-2 / JARA-HPC},
      ddc          = {000},
      cid          = {I:(DE-Juel1)ICS-2-20110106 / $I:(DE-82)080012_20140620$},
      pnm          = {552 - Engineering Cell Function (POF3-552) / Blood Flow
                      Resistance in Microvascular Networks $(jics21_20131101)$},
      pid          = {G:(DE-HGF)POF3-552 / $G:(DE-Juel1)jics21_20131101$},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000385171400001},
      pubmed       = {pmid:27708337},
      doi          = {10.1038/srep34375},
      url          = {https://juser.fz-juelich.de/record/820533},
}