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@ARTICLE{Gravagnuolo:821017,
author = {Gravagnuolo, Alfredo Maria and Longobardi, Sara and
Luchini, Alessandra and Appavou, Marie-Sousai and De
Stefano, Luca and Notomista, Eugenio and Paduano, Luigi and
Giardina, Paola},
title = {{C}lass {I} {H}ydrophobin {V}mh2 {A}dopts {A}typical
{M}echanisms to {S}elf-{A}ssemble into {F}unctional
{A}myloid {F}ibrils},
journal = {Biomacromolecules},
volume = {17},
number = {3},
issn = {1526-4602},
address = {Columbus, Ohio},
publisher = {American Chemical Soc.},
reportid = {FZJ-2016-06274},
pages = {954 - 964},
year = {2016},
abstract = {Hydrophobins are fungal proteins whose functions are mainly
based on their capability to self-assemble into amphiphilic
films at hydrophobic–hydrophilic interfaces (HHI). It is
widely accepted that class I hydrophobins form amyloid-like
structures, named rodlets, which are hundreds of nanometers
long, packed into ordered lateral assemblies and do not
exhibit an overall helical structure. We studied the
self-assembly of the Class I hydrophobin Vmh2 from Pleurotus
ostreatus in aqueous solutions by dynamic light scattering
(DLS), thioflavin T (ThT), fluorescence assay, circular
dichroism (CD), cryogenic trasmission electron microscopy
(cryo-TEM), and TEM. Vmh2 does not form fibrillar aggregates
at HHI. It exhibits spherical and fibrillar assemblies whose
ratio depends on the protein concentration when freshly
solubilized at pH ≥ 7. Moreover, it spontaneously
self-assembles into isolated, micrometer long, and twisted
amyloid fibrils, observed for the first time in fungal
hydrophobins. This process is promoted by acidic pH,
temperature, and Ca2+ ions. A model of self-assembly into
amyloid-like structures has been proposed.},
cin = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
(München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
ddc = {540},
cid = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
I:(DE-Juel1)JCNS-1-20110106},
pnm = {6G15 - FRM II / MLZ (POF3-6G15) / 6G4 - Jülich Centre for
Neutron Research (JCNS) (POF3-623)},
pid = {G:(DE-HGF)POF3-6G15 / G:(DE-HGF)POF3-6G4},
experiment = {EXP:(DE-MLZ)TEM-MLZ-20151210},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000372391800027},
pubmed = {pmid:26828412},
doi = {10.1021/acs.biomac.5b01632},
url = {https://juser.fz-juelich.de/record/821017},
}