000821077 001__ 821077
000821077 005__ 20220930130110.0
000821077 0247_ $$2doi$$a10.1038/srep33474
000821077 0247_ $$2Handle$$a2128/12866
000821077 0247_ $$2WOS$$aWOS:000383383100001
000821077 0247_ $$2altmetric$$aaltmetric:12083365
000821077 0247_ $$2pmid$$apmid:27641459
000821077 037__ $$aFZJ-2016-06321
000821077 082__ $$a000
000821077 1001_ $$0P:(DE-HGF)0$$aMirecka, Ewa A.$$b0
000821077 245__ $$aβ-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation Inhibitor
000821077 260__ $$aLondon$$bNature Publishing Group$$c2016
000821077 3367_ $$2DRIVER$$aarticle
000821077 3367_ $$2DataCite$$aOutput Types/Journal article
000821077 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1479373690_19619
000821077 3367_ $$2BibTeX$$aARTICLE
000821077 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000821077 3367_ $$00$$2EndNote$$aJournal Article
000821077 520__ $$aIn type 2 diabetes, the formation of islet amyloid consisting of islet amyloid polypeptide (IAPP) isassociated with reduction in β-cell mass and contributes to the failure of islet cell transplantation.Rational design of inhibitors of IAPP amyloid formation has therapeutic potential, but is hampered bythe lack of structural information on inhibitor complexes of the conformationally flexible, aggregationproneIAPP. Here we characterize a β-hairpin conformation of IAPP in complex with the engineeredbinding protein β-wrapin HI18. The β-strands correspond to two amyloidogenic motifs, 12-LANFLVH-18and 22-NFGAILS-28, which are connected by a turn established around Ser-20. Besides backbonehydrogen bonding, the IAPP:HI18 interaction surface is dominated by non-polar contacts involvinghydrophobic side chains of the IAPP β-strands. Apart from monomers, HI18 binds oligomers and fibrilsand inhibits IAPP aggregation and toxicity at low substoichiometric concentrations. The IAPP β-hairpincan serve as a molecular recognition motif enabling control of IAPP aggregation.
000821077 536__ $$0G:(DE-HGF)POF3-553$$a553 - Physical Basis of Diseases (POF3-553)$$cPOF3-553$$fPOF III$$x0
000821077 588__ $$aDataset connected to CrossRef
000821077 7001_ $$0P:(DE-Juel1)162167$$aFeuerstein, Sophie$$b1$$ufzj
000821077 7001_ $$0P:(DE-Juel1)145165$$aGremer, Lothar$$b2$$ufzj
000821077 7001_ $$0P:(DE-HGF)0$$aSchröder, Gunnar F.$$b3
000821077 7001_ $$0P:(DE-Juel1)132023$$aStoldt, Matthias$$b4$$ufzj
000821077 7001_ $$0P:(DE-Juel1)132029$$aWillbold, Dieter$$b5$$ufzj
000821077 7001_ $$0P:(DE-Juel1)166306$$aHoyer, Wolfgang$$b6$$eCorresponding author$$ufzj
000821077 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/srep33474$$gVol. 6, p. 33474 -$$p33474 -$$tScientific reports$$v6$$x2045-2322$$y2016
000821077 8564_ $$uhttps://juser.fz-juelich.de/record/821077/files/srep33474.pdf$$yOpenAccess
000821077 8564_ $$uhttps://juser.fz-juelich.de/record/821077/files/srep33474.gif?subformat=icon$$xicon$$yOpenAccess
000821077 8564_ $$uhttps://juser.fz-juelich.de/record/821077/files/srep33474.jpg?subformat=icon-1440$$xicon-1440$$yOpenAccess
000821077 8564_ $$uhttps://juser.fz-juelich.de/record/821077/files/srep33474.jpg?subformat=icon-180$$xicon-180$$yOpenAccess
000821077 8564_ $$uhttps://juser.fz-juelich.de/record/821077/files/srep33474.jpg?subformat=icon-640$$xicon-640$$yOpenAccess
000821077 8564_ $$uhttps://juser.fz-juelich.de/record/821077/files/srep33474.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000821077 8767_ $$8214437OI$$92016-09-01$$d2016-09-02$$eAPC$$jZahlung erfolgt
000821077 909CO $$ooai:juser.fz-juelich.de:821077$$popenCost$$pVDB$$pdriver$$pOpenAPC$$popen_access$$popenaire$$pdnbdelivery
000821077 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)162167$$aForschungszentrum Jülich$$b1$$kFZJ
000821077 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)145165$$aForschungszentrum Jülich$$b2$$kFZJ
000821077 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)132023$$aForschungszentrum Jülich$$b4$$kFZJ
000821077 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)132029$$aForschungszentrum Jülich$$b5$$kFZJ
000821077 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)166306$$aForschungszentrum Jülich$$b6$$kFZJ
000821077 9131_ $$0G:(DE-HGF)POF3-553$$1G:(DE-HGF)POF3-550$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lBioSoft – Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences$$vPhysical Basis of Diseases$$x0
000821077 9141_ $$y2016
000821077 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000821077 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000821077 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000821077 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record
000821077 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bSCI REP-UK : 2015
000821077 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bSCI REP-UK : 2015
000821077 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal
000821077 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ
000821077 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000821077 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000821077 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000821077 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000821077 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences
000821077 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000821077 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000821077 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000821077 920__ $$lyes
000821077 9201_ $$0I:(DE-Juel1)ICS-6-20110106$$kICS-6$$lStrukturbiochemie $$x0
000821077 9801_ $$aFullTexts
000821077 980__ $$ajournal
000821077 980__ $$aVDB
000821077 980__ $$aUNRESTRICTED
000821077 980__ $$aI:(DE-Juel1)ICS-6-20110106
000821077 980__ $$aAPC
000821077 981__ $$aI:(DE-Juel1)IBI-7-20200312