% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Taylor:821080,
      author       = {Taylor, Alexander J. and Granwehr, Josef and Lesbats,
                      Clémentine and Krupa, James L. and Six, Joseph S. and
                      Pavlovskaya, Galina E. and Thomas, Neil R. and Auer,
                      Dorothee P. and Meersmann, Thomas and Faas, Henryk M.},
      title        = {{P}robe-{S}pecific {P}rocedure to {E}stimate {S}ensitivity
                      and {D}etection {L}imits for 19{F} {M}agnetic {R}esonance
                      {I}maging},
      journal      = {PLoS one},
      volume       = {11},
      number       = {10},
      issn         = {1932-6203},
      address      = {Lawrence, Kan.},
      publisher    = {PLoS},
      reportid     = {FZJ-2016-06324},
      pages        = {e0163704 -},
      year         = {2016},
      abstract     = {Due to low fluorine background signal in vivo, 19F is a
                      good marker to study the fate of exogenous molecules by
                      magnetic resonance imaging (MRI) using equilibrium nuclear
                      spin polarization schemes. Since 19F MRI applications
                      require high sensitivity, it can be important to assess
                      experimental feasibility during the design stage already by
                      estimating the minimum detectable fluorine concentration.
                      Here we propose a simple method for the calibration of MRI
                      hardware, providing sensitivity estimates for a given
                      scanner and coil configuration. An experimental
                      “calibration factor” to account for variations in coil
                      configuration and hardware set-up is specified. Once it has
                      been determined in a calibration experiment, the sensitivity
                      of an experiment or, alternatively, the minimum number of
                      required spins or the minimum marker concentration can be
                      estimated without the need for a pilot experiment. The
                      definition of this calibration factor is derived based on
                      standard equations for the sensitivity in magnetic
                      resonance, yet the method is not restricted by the limited
                      validity of these equations, since additional
                      instrument-dependent factors are implicitly included during
                      calibration. The method is demonstrated using MR
                      spectroscopy and imaging experiments with different 19F
                      samples, both paramagnetically and susceptibility broadened,
                      to approximate a range of realistic environments.},
      cin          = {IEK-9},
      ddc          = {500},
      cid          = {I:(DE-Juel1)IEK-9-20110218},
      pnm          = {131 - Electrochemical Storage (POF3-131)},
      pid          = {G:(DE-HGF)POF3-131},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000385504400009},
      pubmed       = {pmid:27727294},
      doi          = {10.1371/journal.pone.0163704},
      url          = {https://juser.fz-juelich.de/record/821080},
}