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@ARTICLE{Lohmann:821108,
      author       = {Lohmann, P. and Willuweit, A. and Neffe, A. T. and Geisler,
                      S. and Gebauer, T. P. and Beer, S. and Coenen, H. H. and
                      Fischer, H. and Hermanns-Sachweh, B. and Lendlein, A. and
                      Shah, N. J. and Kiessling, F. and Langen, K.-J.},
      title        = {{B}one regeneration induced by a 3{D} architectured
                      hydrogel in a rat critical-size calvarial defect},
      journal      = {Biomaterials},
      volume       = {113},
      issn         = {0142-9612},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2016-06351},
      pages        = {158 - 169},
      year         = {2017},
      abstract     = {Bone regeneration can be stimulated by implantation of
                      biomaterials, which is especially important for larger bone
                      defects. Here, healing potency of the porous ArcGel was
                      evaluated in a critical-size calvarial bone defect in rats
                      in comparison with clinical standard autologous bone and
                      Bio-Oss® Collagen (BioOss), a bone graft material
                      frequently used in clinics. Bone healing and metabolic
                      processes involved were monitored longitudinally by
                      [18F]-fluoride and [18F]-FDG μ-PET/CT 1d, 3d, 3w, 6w, and
                      12w post implantation. Differences in quality of bone
                      healing were assessed by ex vivo μ-CT, mechanical tests and
                      histomorphometry. The amount of bone formed after
                      implantation of ArcGel was comparable to autologous bone and
                      superior to BioOss (histomorphometry). Furthermore,
                      microarchitecture of newly formed bone was more
                      physiological and better functional in case of ArcGel
                      (push-out tests). [18F]-FDG uptake increased until 3d after
                      implantation, and decreased until 12w for both ArcGel and
                      BioOss. [18F]-fluoride uptake increased until 3w post
                      implantation for all materials, but persisted significantly
                      longer at higher levels for BioOss, which indicates a
                      prolonged remodelling phase. The study demonstrates the
                      potential of ArcGel to induce restitutio ad integrum
                      comparable with clinical standard autologous bone and better
                      bone regeneration in large defects compared to a commercial
                      state-of-the-art biomaterial.},
      cin          = {INM-2 / INM-4 / INM-5 / JARA-BRAIN},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-2-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)INM-5-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000389396300013},
      pubmed       = {pmid:27815999},
      doi          = {10.1016/j.biomaterials.2016.10.039},
      url          = {https://juser.fz-juelich.de/record/821108},
}