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000823867 1001_ $$0P:(DE-HGF)0$$aWallin, C.$$b0
000823867 245__ $$aCharacterization of Mn(II) ion binding to the amyloid-ß peptide in Alzheimer’s disease
000823867 260__ $$aMünchen$$bElsevier$$c2016
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000823867 520__ $$aGrowing evidence links neurodegenerative diseases to metal exposure. Aberrant metal ion concentrationshave been noted in Alzheimer’s disease (AD) brains, yet the role of metals in AD pathogenesis remainsunresolved. A major factor in AD pathogenesis is considered to be aggregation of and amyloid formationby amyloid-ß (Aß) peptides. Previous studies have shown that Aß displays specific binding to Cu(II)and Zn(II) ions, and such binding has been shown to modulate Aß aggregation. Here, we use nuclearmagnetic resonance (NMR) spectroscopy to show that Mn(II) ions also bind to the N-terminal part ofthe Aß(1–40) peptide, with a weak binding affinity in the milli- to micromolar range. Circular dichroism(CD) spectroscopy, solid state atomic force microscopy (AFM), fluorescence spectroscopy, and molecularmodeling suggest that the weak binding of Mn(II) to Aß may not have a large effect on the peptide’saggregation into amyloid fibrils. However, identification of an additional metal ion displaying Aß bindingreveals more complex AD metal chemistry than has been previously considered in the literature.
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000823867 7001_ $$0P:(DE-HGF)0$$aKulkarni, Y. S.$$b1
000823867 7001_ $$0P:(DE-HGF)0$$aAbelein, A$$b2
000823867 7001_ $$0P:(DE-HGF)0$$aJarvet, J.$$b3
000823867 7001_ $$0P:(DE-Juel1)145225$$aLiao, Qinghua$$b4
000823867 7001_ $$0P:(DE-Juel1)132024$$aStrodel, Birgit$$b5$$ufzj
000823867 7001_ $$0P:(DE-HGF)0$$aOlsson, L.$$b6
000823867 7001_ $$0P:(DE-HGF)0$$aLuo, J.$$b7
000823867 7001_ $$0P:(DE-HGF)0$$aAbrahams, J. P.$$b8
000823867 7001_ $$0P:(DE-HGF)0$$aSholts, S. B.$$b9
000823867 7001_ $$0P:(DE-HGF)0$$aRoos, P. M.$$b10
000823867 7001_ $$0P:(DE-HGF)0$$aKamerlin, S. C. L.$$b11
000823867 7001_ $$0P:(DE-HGF)0$$aGräslund, A.$$b12
000823867 7001_ $$0P:(DE-HGF)0$$aWärmländer, S. K. T. S.$$b13$$eCorresponding author
000823867 773__ $$0PERI:(DE-600)2174174-8$$a10.1016/j.jtemb.2016.03.009$$p183-193$$tJournal of trace elements in medicine and biology$$v38$$x0946-672X$$y2016
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