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@ARTICLE{Kravchenko:823892,
      author       = {Kravchenko, Kateryna and Kulawik, Andreas and Hülsemann,
                      Maren and Kühbach, Katja and Zafiu, Christian and Herrmann,
                      Yvonne and Linnartz, Christina and Peters, Luriano and
                      Bujnicki, Tuyen and Willbold, Johannes and Bannach, Oliver
                      and Willbold, Dieter},
      title        = {{A}nalysis of anticoagulants for blood-based quantitation
                      of amyloid β oligomers in the s{FIDA} assay},
      journal      = {Biological chemistry},
      volume       = {398},
      number       = {4},
      issn         = {1437-4315},
      address      = {Berlin [u.a.]},
      publisher    = {de Gruyter},
      reportid     = {FZJ-2016-06524},
      pages        = {465–475},
      year         = {2017},
      abstract     = {Early diagnostics at the preclinical stage of Alzheimer’s
                      disease is of utmost importance for drug development in
                      clinical trials and prognostic guidance. Since soluble Aβ
                      oligomers are considered to play a crucial role in the
                      disease pathogenesis, several methods aim to quantify Aβ
                      oligomers in body fluids such as cerebrospinal fluid (CSF)
                      and blood plasma. The highly specific and sensitive method
                      surface-based fluorescence intensity distribution analysis
                      (sFIDA) has successfully been established for oligomer
                      quantitation in CSF samples. In our study, we explored the
                      sFIDA method for quantitative measurements of synthetic Aβ
                      particles in blood plasma. For this purpose, EDTA, citrate
                      and heparin treated blood plasma samples from five
                      individual donors were spiked with Aβ coated silica
                      nanoparticles (Aβ-SiNaPs) and were applied to the sFIDA
                      assay. Based on the assay parameters linearity, coefficient
                      of variation and limit of detection, we found that EDTA
                      plasma yields the most suitable parameter values for
                      quantitation of Aβ oligomers in sFIDA assay with a limit of
                      detection of 16 fM.},
      cin          = {ICS-6},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {553 - Physical Basis of Diseases (POF3-553)},
      pid          = {G:(DE-HGF)POF3-553},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000397610800005},
      pubmed       = {pmid:27811340},
      doi          = {10.1515/hsz-2016-0153},
      url          = {https://juser.fz-juelich.de/record/823892},
}