000823897 001__ 823897
000823897 005__ 20210129224901.0
000823897 0247_ $$2doi$$a10.1016/j.bbamem.2016.11.007
000823897 0247_ $$2WOS$$aWOS:000392772100006
000823897 0247_ $$2altmetric$$aaltmetric:15233519
000823897 0247_ $$2pmid$$apmid:27865700
000823897 037__ $$aFZJ-2016-06529
000823897 041__ $$aEnglish
000823897 082__ $$a570
000823897 1001_ $$0P:(DE-HGF)0$$aPreu, Julia$$b0$$eCorresponding author
000823897 245__ $$aAdhesion ability of angiotensin II with model membranes
000823897 260__ $$aAmsterdam$$bElsevier$$c2016
000823897 3367_ $$2DRIVER$$aarticle
000823897 3367_ $$2DataCite$$aOutput Types/Journal article
000823897 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1488881523_24234
000823897 3367_ $$2BibTeX$$aARTICLE
000823897 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000823897 3367_ $$00$$2EndNote$$aJournal Article
000823897 520__ $$aThe octa-peptide angiotensin II (Ang II, (H2N-Asp–Arg–Val–Tyr–Ile–His–Pro–Phe–COOH)) is one of the key player on blood pressure regulation in mammals.Predominantly binding to the Angiotensin type 1 and 2 receptors, the hormone is oneof several peptide ligands binding to G protein coupled receptors (GPCR). The activehormone derives from a high molecular weight precursor sequentially cleaved by theproteases renin and the angiotensin converting enzyme (ACE). The chemical natureof the amino acid sequence has an impact on the behavior in the proximity ofmembranes, demonstrated using different membrane model systems and biophysicalmethods.Applying electrochemical impedance spectroscopy and small angle x-ray scattering adetailed view on the adhesion of the peptide with model membrane surfaces wasperformed. The role of specific amino acids involved in the interaction with thephospholipid head group were investigated and, studying a truncated version of AngII, Ang (1-7), the key role of the C-terminal phenylalanine was proven. Truncation ofthe C-terminal amino acid abolishes the binding of the peptide to the membranesurface. A shift in pH, altering the protonation state of the central histidine residueimpairs the adhesion of Ang II.
000823897 536__ $$0G:(DE-HGF)POF3-6215$$a6215 - Soft Matter, Health and Life Sciences (POF3-621)$$cPOF3-621$$fPOF III$$x0
000823897 536__ $$0G:(DE-HGF)POF3-6G4$$a6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)$$cPOF3-623$$fPOF III$$x1
000823897 65027 $$0V:(DE-MLZ)SciArea-160$$2V:(DE-HGF)$$aBiology$$x0
000823897 65017 $$0V:(DE-MLZ)GC-130-2016$$2V:(DE-HGF)$$aHealth and Life$$x0
000823897 693__ $$0EXP:(DE-MLZ)NOSPEC-20140101$$5EXP:(DE-MLZ)NOSPEC-20140101$$eNo specific instrument$$x0
000823897 7001_ $$0P:(DE-HGF)0$$aTiefenauer, Louis$$b1
000823897 7001_ $$0P:(DE-Juel1)168124$$aGutberlet, Thomas$$b2
000823897 773__ $$0PERI:(DE-600)2209384-9$$a10.1016/j.bbamem.2016.11.007$$p195$$tBiochimica et biophysica acta / Biomembranes$$v1859$$x0005-2736$$y2016
000823897 8564_ $$uhttps://juser.fz-juelich.de/record/823897/files/Preu_BBA_2016.pdf$$yRestricted
000823897 8564_ $$uhttps://juser.fz-juelich.de/record/823897/files/Preu_BBA_2016.gif?subformat=icon$$xicon$$yRestricted
000823897 8564_ $$uhttps://juser.fz-juelich.de/record/823897/files/Preu_BBA_2016.jpg?subformat=icon-1440$$xicon-1440$$yRestricted
000823897 8564_ $$uhttps://juser.fz-juelich.de/record/823897/files/Preu_BBA_2016.jpg?subformat=icon-180$$xicon-180$$yRestricted
000823897 8564_ $$uhttps://juser.fz-juelich.de/record/823897/files/Preu_BBA_2016.jpg?subformat=icon-640$$xicon-640$$yRestricted
000823897 8564_ $$uhttps://juser.fz-juelich.de/record/823897/files/Preu_BBA_2016.pdf?subformat=pdfa$$xpdfa$$yRestricted
000823897 909CO $$ooai:juser.fz-juelich.de:823897$$pVDB$$pVDB:MLZ
000823897 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)168124$$aForschungszentrum Jülich$$b2$$kFZJ
000823897 9131_ $$0G:(DE-HGF)POF3-621$$1G:(DE-HGF)POF3-620$$2G:(DE-HGF)POF3-600$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF3-6215$$aDE-HGF$$bForschungsbereich Materie$$lVon Materie zu Materialien und Leben$$vIn-house research on the structure, dynamics and function of matter$$x0
000823897 9131_ $$0G:(DE-HGF)POF3-623$$1G:(DE-HGF)POF3-620$$2G:(DE-HGF)POF3-600$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF3-6G4$$aDE-HGF$$bForschungsbereich Materie$$lVon Materie zu Materialien und Leben$$vFacility topic: Neutrons for Research on Condensed Matter$$x1
000823897 9141_ $$y2017
000823897 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000823897 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bBBA-BIOMEMBRANES : 2015
000823897 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000823897 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000823897 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000823897 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000823897 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000823897 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000823897 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000823897 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000823897 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000823897 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000823897 9201_ $$0I:(DE-Juel1)JCNS-FRM-II-20110218$$kJCNS (München) ; Jülich Centre for Neutron Science JCNS (München) ; JCNS-FRM-II$$lJCNS-FRM-II$$x0
000823897 9201_ $$0I:(DE-Juel1)JCNS-1-20110106$$kNeutronenstreuung ; JCNS-1$$lNeutronenstreuung $$x1
000823897 9201_ $$0I:(DE-Juel1)JCNS-2-20110106$$kJCNS-2$$lStreumethoden$$x2
000823897 980__ $$ajournal
000823897 980__ $$aVDB
000823897 980__ $$aI:(DE-Juel1)JCNS-FRM-II-20110218
000823897 980__ $$aI:(DE-Juel1)JCNS-1-20110106
000823897 980__ $$aI:(DE-Juel1)JCNS-2-20110106
000823897 980__ $$aUNRESTRICTED
000823897 981__ $$aI:(DE-Juel1)JCNS-FRM-II-20110218