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@ARTICLE{Lanotte:824053,
      author       = {Lanotte, Luca and Mauer, Johannes and Mendez, Simon and
                      Fedosov, Dmitry A. and Fromental, Jean-Marc and Claveria,
                      Viviana and Nicoud, Franck and Gompper, Gerhard and
                      Abkarian, Manouk},
      title        = {{R}ed cells' dynamic morphologies govern blood shear
                      thinning under microcirculatory flow conditions},
      journal      = {Proceedings of the National Academy of Sciences of the
                      United States of America},
      volume       = {113},
      number       = {47},
      issn         = {1091-6490},
      address      = {Washington, DC},
      publisher    = {National Acad. of Sciences},
      reportid     = {FZJ-2016-06677},
      pages        = {13289 - 13294},
      year         = {2016},
      abstract     = {Blood viscosity decreases with shear stress, a property
                      essential for an efficient perfusion of the vascular tree.
                      Shear thinning is intimately related to the dynamics and
                      mutual interactions of RBCs, the major component of blood.
                      Because of the lack of knowledge about the behavior of RBCs
                      under physiological conditions, the link between RBC
                      dynamics and blood rheology remains unsettled. We performed
                      experiments and simulations in microcirculatory flow
                      conditions of viscosity, shear rates, and volume fractions,
                      and our study reveals rich RBC dynamics that govern shear
                      thinning. In contrast to the current paradigm, which assumes
                      that RBCs align steadily around the flow direction while
                      their membranes and cytoplasm circulate, we show that RBCs
                      successively tumble, roll, deform into rolling stomatocytes,
                      and, finally, adopt highly deformed polylobed shapes for
                      increasing shear stresses, even for semidilute volume
                      fractions of the microcirculation. Our results suggest that
                      any pathological change in plasma composition, RBC cytosol
                      viscosity, or membrane mechanical properties will affect the
                      onset of these morphological transitions and should play a
                      central role in pathological blood rheology and flow
                      behavior.},
      cin          = {ICS-2},
      ddc          = {000},
      cid          = {I:(DE-Juel1)ICS-2-20110106},
      pnm          = {553 - Physical Basis of Diseases (POF3-553)},
      pid          = {G:(DE-HGF)POF3-553},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000388830700047},
      pubmed       = {pmid:27834220},
      doi          = {10.1073/pnas.1608074113},
      url          = {https://juser.fz-juelich.de/record/824053},
}