TY  - JOUR
AU  - Jaksch, Sebastian
AU  - Schulz, Anita
AU  - Di, Zhenyu
AU  - Luxenhofer, Robert
AU  - Jordan, Rainer
AU  - Papadakis, Christine M.
TI  - Amphiphilic Triblock Copolymers from Poly(2-oxazoline) with Different Hydrophobic Blocks: Changes of the Micellar Structures upon Addition of a Strongly Hydrophobic Cancer Drug
JO  - Macromolecular chemistry and physics
VL  - 217
IS  - 13
SN  - 1022-1352
CY  - Weinheim
PB  - Wiley-VCH
M1  - FZJ-2016-06702
SP  - 1448 - 1456
PY  - 2016
AB  - AbstractimageAmphiphilic triblock copolymers with poly(2-methyl-2-oxazoline) (MeOx) end blocks and a poly(2-n-butyl-2-oxazoline) (nBuOx) middle block have been found to solubilize large amounts of the cancer drug paclitaxel (PTX) whereas this is not the case when the middle block is more hydrophobic, such as poly(2-n-nonyl-2-oxazoline) (NOx) (Schulz et al., ACS Nano2014, 8, 2686). To further elucidate the origin of this behavior, dilute aqueous solutions (5–10 mg mL−1) of these two copolymers have been investigated by small-angle neutron scattering (SANS), both in the absence and presence of PTX. Whereas PMeOx-b-PNOx-b-PMeOx forms mainly worm-like micelles coexisting with large aggregates, spherical micelles are predominant in PMeOx-b-PnBuOx-b-PMeOx. Already small PTX concentrations lead to shape changes in PMeOx-b-PNOx-b-PMeOx toward spherical micelles. In contrast, changes in the aggregation behavior of PMeOx-b-PnBuOx-b-PMeOx are only observed at higher PTX concentrations with a transformation into raspberry-like particles, which may explain the high PTX loading capacity of PMeOx-b-PnBuOx-b-PMeOx micelles.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000380017700003
DO  - DOI:10.1002/macp.201500465
UR  - https://juser.fz-juelich.de/record/824078
ER  -