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@ARTICLE{Jaksch:824078,
      author       = {Jaksch, Sebastian and Schulz, Anita and Di, Zhenyu and
                      Luxenhofer, Robert and Jordan, Rainer and Papadakis,
                      Christine M.},
      title        = {{A}mphiphilic {T}riblock {C}opolymers from
                      {P}oly(2-oxazoline) with {D}ifferent {H}ydrophobic {B}locks:
                      {C}hanges of the {M}icellar {S}tructures upon {A}ddition of
                      a {S}trongly {H}ydrophobic {C}ancer {D}rug},
      journal      = {Macromolecular chemistry and physics},
      volume       = {217},
      number       = {13},
      issn         = {1022-1352},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {FZJ-2016-06702},
      pages        = {1448 - 1456},
      year         = {2016},
      abstract     = {AbstractimageAmphiphilic triblock copolymers with
                      poly(2-methyl-2-oxazoline) (MeOx) end blocks and a
                      poly(2-n-butyl-2-oxazoline) (nBuOx) middle block have been
                      found to solubilize large amounts of the cancer drug
                      paclitaxel (PTX) whereas this is not the case when the
                      middle block is more hydrophobic, such as
                      poly(2-n-nonyl-2-oxazoline) (NOx) (Schulz et al., ACS
                      Nano2014, 8, 2686). To further elucidate the origin of this
                      behavior, dilute aqueous solutions (5–10 mg mL−1) of
                      these two copolymers have been investigated by small-angle
                      neutron scattering (SANS), both in the absence and presence
                      of PTX. Whereas PMeOx-b-PNOx-b-PMeOx forms mainly worm-like
                      micelles coexisting with large aggregates, spherical
                      micelles are predominant in PMeOx-b-PnBuOx-b-PMeOx. Already
                      small PTX concentrations lead to shape changes in
                      PMeOx-b-PNOx-b-PMeOx toward spherical micelles. In contrast,
                      changes in the aggregation behavior of
                      PMeOx-b-PnBuOx-b-PMeOx are only observed at higher PTX
                      concentrations with a transformation into raspberry-like
                      particles, which may explain the high PTX loading capacity
                      of PMeOx-b-PnBuOx-b-PMeOx micelles.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {6G15 - FRM II / MLZ (POF3-6G15) / 6G4 - Jülich Centre for
                      Neutron Research (JCNS) (POF3-623)},
      pid          = {G:(DE-HGF)POF3-6G15 / G:(DE-HGF)POF3-6G4},
      experiment   = {EXP:(DE-MLZ)KWS1-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000380017700003},
      doi          = {10.1002/macp.201500465},
      url          = {https://juser.fz-juelich.de/record/824078},
}