% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Schfer:824108,
      author       = {Schäfer, Dominique and Weiß, Philipp and Ermert, Johannes
                      and Castillo, Johnny and Zarrad, Fadi and Neumaier, Bernd},
      title        = {{P}reparation of {N}o-{C}arrier-{A}dded 6-[$^{18}$
                      {F}]{F}luoro- l -tryptophan via {C}u-{M}ediated
                      {R}adiofluorination},
      journal      = {European journal of organic chemistry},
      volume       = {2016},
      number       = {27},
      issn         = {1434-193X},
      address      = {Weinheim},
      publisher    = {Wiley-VCH Verl.},
      reportid     = {FZJ-2016-06732},
      pages        = {4621 - 4628},
      year         = {2016},
      abstract     = {18F-Labeled aromatic amino acids exhibit great potential
                      for diagnostic applications using positron emission
                      tomography. However, the introduction of 18F into aromatic
                      compounds remains challenging, and novel fluorination
                      methods facilitating easy access to 18F-labeled arenes are
                      highly sought after. In recent years, novel metal-mediated
                      fluorination methods have been reported and transferred into
                      radiochemistry. Based on Cu-mediated radiofluorination, a
                      two-step synthesis of no-carrier-added (n.c.a.)
                      6-[18F]fluoro-l-tryptophan was developed.
                      6-[18F]Fluoro-l-tryptophan was synthesized with an overall
                      radochemical yield of $16 ± 4\%$ within 110 min and a
                      specific activity of 280 GBq µmol–1. The radiochemical
                      purity was more than $99 \%.$ The developed method allowed
                      access to radiofluorinated tryptophan derivatives in high
                      radiochemical yields and opens new ways to provide
                      radiofluorinated amino acids. Furthermore, the reaction
                      conditions were optimized to facilitate automation.},
      cin          = {INM-5},
      ddc          = {540},
      cid          = {I:(DE-Juel1)INM-5-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000384549600005},
      doi          = {10.1002/ejoc.201600705},
      url          = {https://juser.fz-juelich.de/record/824108},
}