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@ARTICLE{Cavani:824538,
      author       = {Cavani, Melanie and Bier, Dirk and Holschbach, Marcus and
                      Coenen, Heinrich Hubert},
      title        = {{E}fficient synthesis of [$^{18}$ {F}]{FP}y{ME}: {A} new
                      approach for the preparation of maleimide-containing
                      prosthetic groups for the conjugation with thiols},
      journal      = {Journal of labelled compounds and radiopharmaceuticals},
      volume       = {60},
      number       = {1},
      issn         = {0362-4803},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley},
      reportid     = {FZJ-2016-07110},
      pages        = {87-92},
      year         = {2017},
      abstract     = {An improved high yielding radiosynthesis of the known
                      thiol-reactive maleimide-containing prosthetic
                      group1-[3-(2-[18F]fluoropyridine-3-yloxy)propyl]pyrrole-2,5-dione
                      ([18F]FPyME) is described. The target compound was obtained
                      by a two-step one-pot procedure starting from a
                      maleimide-containing nitro-precursor that was protected as a
                      Diels-Alder adduct with 2,5-dimethylfurane. Nucleophilic
                      radiofluorination followed by heat induced deprotection
                      through a Retro Diels Alder reaction yielded, after
                      chromatographic isolation, [18F]FPyME with a radiochemical
                      yield of $20\%$ in about 60 min overall synthesis time. A
                      variety of other [18F]fluoropyridine based
                      maleimide-containing prosthetic groups should be accessible
                      via the described synthetic strategy.},
      cin          = {INM-5},
      ddc          = {540},
      cid          = {I:(DE-Juel1)INM-5-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000393835900011},
      doi          = {10.1002/jlcr.3469},
      url          = {https://juser.fz-juelich.de/record/824538},
}