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@ARTICLE{Sawicki:824545,
      author       = {Sawicki, Lino M. and Buchbender, Christian and Boos,
                      Johannes and Giessing, Markus and Ermert, Johannes and
                      Antke, Christina and Antoch, Gerald and Hautzel, Hubertus},
      title        = {{D}iagnostic potential of {PET}/{CT} using a
                      $^{68}${G}a-labelled prostate-specific membrane antigen
                      ligand in whole-body staging of renal cell carcinoma:
                      initial experience},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {44},
      number       = {1},
      issn         = {1619-7089},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {FZJ-2016-07117},
      pages        = {102 - 107},
      year         = {2017},
      abstract     = {Purpose To evaluate the diagnostic potential of
                      whole-bodyPET/CT using a 68Ga-labelled PSMA ligand in renal
                      cell carcinoma(RCC).Methods Six patients with
                      histopathologically proven RCCunderwent 68Ga-PSMA PET/CT.
                      Each PET/CT scan wasevaluated in relation to lesion count,
                      location and dignity.SUVmax was measured in primary tumours
                      and PETpositivemetastases. Tumour-to-background SUVmax
                      ratios(TBRSUVmax) were calculated for primary RCCs in
                      relationto the surrounding normal renal parenchyma.
                      Metastasis-tobackgroundSUVmax ratios (MBRSUVmax) were
                      calculatedfor PET-positive metastases in relation to gluteal
                      muscle.Results Five primary RCCs and 16 metastases were
                      evaluated.The mean SUVmax of the primary RCCs was 9.9 ±
                      9.2(range 1.7 – 27.2). Due to high uptake in the
                      surrounding renalparenchyma, the mean TBRSUVmax of the
                      primary RCCs wasonly 0.2 ± 0.3 (range 0.02 – 0.7). Eight
                      metastases showed focal68Ga-PSMA uptake (SUVmax 9.9 ± 8.3,
                      range 3.4 – 25.6).The mean MBRSUVmax of these PET-positive
                      metastases was11.7 ± 0.2 (range 4.4 – 28.1). All
                      PET-negative metastaseswere subcentimetre lung
                      metastases.Conclusion 68Ga-PSMA PET/CT appears to be a
                      promisingmethod for detecting RCC metastases. However, no
                      additionaldiagnostic value in assessing the primary tumour
                      was found.},
      cin          = {INM-5 / KME},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-5-20090406 / I:(DE-Juel1)VDB145},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000389242200013},
      pubmed       = {pmid:26996777},
      doi          = {10.1007/s00259-016-3360-2},
      url          = {https://juser.fz-juelich.de/record/824545},
}