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@ARTICLE{Bucciarelli:824671,
      author       = {Bucciarelli, S. and Myung, J. S. and Farago, B. and Das, S.
                      and Vliegenthart, Gerrit and Holderer, O. and Winkler, R. G.
                      and Schurtenberger, P. and Gompper, G. and Stradner, A.},
      title        = {{D}ramatic influence of patchy attractions on short-time
                      protein diffusion under crowded conditions},
      journal      = {Science advances},
      volume       = {2},
      number       = {12},
      issn         = {2375-2548},
      address      = {Washington, DC [u.a.]},
      publisher    = {Assoc.},
      reportid     = {FZJ-2016-07229},
      pages        = {e1601432 - e1601432},
      year         = {2016},
      abstract     = {In the dense and crowded environment of the cell cytoplasm,
                      an individual protein feels the presence of and interacts
                      with all surrounding proteins. While we expect this to
                      strongly influence the short-time diffusion coefficient Ds
                      of proteins on length scales comparable to the
                      nearest-neighbor distance, this quantity is difficult to
                      assess experimentally. We demonstrate that quantitative
                      information about Ds can be obtained from quasi-elastic
                      neutron scattering experiments using the neutron spin echo
                      technique. We choose two well-characterized and highly
                      stable eye lens proteins, bovine α-crystallin and
                      γB-crystallin, and measure their diffusion at
                      concentrations comparable to those present in the eye lens.
                      While diffusion slows down with increasing concentration for
                      both proteins, we find marked variations that are directly
                      linked to subtle differences in their interaction
                      potentials. A comparison with computer simulations shows
                      that anisotropic and patchy interactions play an essential
                      role in determining the local short-time dynamics. Hence,
                      our study clearly demonstrates the enormous effect that weak
                      attractions can have on the short-time diffusion of proteins
                      at concentrations comparable to those in the cellular
                      cytosol.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / ICS-2},
      ddc          = {500},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)ICS-2-20110106},
      pnm          = {6215 - Soft Matter, Health and Life Sciences (POF3-621) /
                      6G15 - FRM II / MLZ (POF3-6G15) / 551 - Functional
                      Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-6215 / G:(DE-HGF)POF3-6G15 /
                      G:(DE-HGF)POF3-551},
      experiment   = {EXP:(DE-MLZ)J-NSE-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000391268800014},
      pubmed       = {pmid:27957539},
      doi          = {10.1126/sciadv.1601432},
      url          = {https://juser.fz-juelich.de/record/824671},
}